CSN1 Antibody, Cy5.5 Conjugated

• Catalog number
  bs-9126R-Cy5.5
• Price
  Please ask
• Size
  0.1ml

• Long name
  CSN1 Polyclonal Antibody, Cy5.5 Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Cy5.5
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  CSN1
• Specificity
  This is a highly specific antibody against CSN1.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  324-370/491
• Source
  KLH conjugated synthetic peptide derived from human CSN1
• Gene ID number
  2873
• Swiss Prot
  Q13098
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  675nm/694nm
• Synonyms
  CSN1; COPS1; COP9 signalosome complex subunit 1; SGN1; Signalosome subunit 1; G protein pathway suppressor 1; GPS-1; JAB1-containing signalosome subunit 1; Protein MFH; GPS1
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.
• Additional conjugation
  Cy5.5, Cy5.5
• Conjugated
  These antibodies are excite for emission at 678nm and detected at a 694 nm wavelengths.
• French translation
  anticorps

• Gene target
  CSN1   Conjugated  
• Gene symbol
  CSN1S1, GPS1
• Short name
  Anti-CSN1
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Cy5.5
• Alternative name
  Anti-CSN1 PAb Cy5.5
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2445
• Gene
  CSN1S1
• Long gene name
  casein alpha s1
• Synonyms gene
  • CASA
  • CSN1
• Synonyms gene name
  • casein, alpha
• GenBank acession
  • X78416
• Locus
  4q13.3
• Discovery year
  1987-09-11
• Entrez gene record
  1446
• Pubmed identfication
  • 9050925
  • 7619062
• VEGA ID
  OTTHUMG00000160843

Gene info

• Identity
  HGNC:4549
• Gene
  GPS1
• Long gene name
  G protein pathway suppressor 1
• Synonyms
  • COPS1
  • CSN1
• Synonyms name
  • COP9 signalosome subunit 1
• Locus
  17q25.3
• Discovery year
  1997-10-10
• Entrez gene record
  2873
• Pubmed identfication
  • 9535219
• RefSeq identity
  • NM_212492
• Classification
  • COP9 signalosome
• VEGA ID
  OTTHUMG00000178484

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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