BLNK(Tyr189) Antibody, Biotin Conjugated

• Catalog number
  bs-9688R-Biotin
• Price
  Please ask
• Size
  0.1ml

• Long name
  BLNK(Tyr189) Polyclonal Antibody, Biotin Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Biotin
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  BLNK Tyr189
• Specificity
  This is a highly specific antibody against BLNK Tyr189.
• Modification
  Phosphorylation
• Modification site
  Tyr189
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human BLNK around the phosphorylation site of Tyr189 [EN(p-Y)IH]
• Gene ID number
  29760
• Tested applications
  WB, IHC-P
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012].
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  N/A
• Synonyms
  BLNK phospho Y491; p-BLNK phospho Y491; B cell adapter containing SH2 domain protein; B cell adapter containing Src homology 2 domain protein; B cell linker; B cell linker protein; B cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; B-cell linker protein; BASH; BASH; Bca; Bca; BLNK; BLNK s; BLNK_HUMAN; Cytoplasmic adapter protein; Ly 57; Ly-57; Ly57; Lymphocyte antigen 57; Lymphocyte antigen-57; Lyw 57; Lyw-57; Lyw57; MGC111051; SLP 65; SLP65; SLP-65; Src homology 2 domain containing leukocyte protein of 65 kDa.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
• Additional conjugation
  Biotinylated
• French translation
  anticorps

• Gene target
  BLNK   Tyr189   Conjugated  
• Gene symbol
  BLNK
• Short name
  Anti-BLNK Tyr189
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Biotin
• Alternative name
  Anti-BLNK Tyr189 PAb Biotin
• Alternative technique
  antibodies
• Alternative to gene target
  B-cell linker, BLNK and IDBG-83724 and ENSG00000095585 and 29760, protein binding, Plasma membranes, Blnk and IDBG-165316 and ENSMUSG00000061132 and 17060, BT.24520 and IDBG-638042 and ENSBTAG00000021358 and 510393

Gene info

• Identity
  HGNC:14211
• Gene
  BLNK
• Long gene name
  B cell linker
• Synonyms
  • SLP65
  • Ly57
  • SLP-65
  • BLNK-s
  • BASH
  • bca
• Synonyms name
  • B-cell adapter containing a SH2 domain protein
  • B-cell activation
  • Src homology [SH2] domain-containing leukocyte protein of 65 kD
  • B cell adaptor containing SH2 domain
• GenBank acession
  • AF068180
• Locus
  10q24.1
• Discovery year
  2001-07-16
• Entrez gene record
  29760
• Pubmed identfication
  • 9697839
  • 10583958
• RefSeq identity
  • NM_013314
• Classification
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000018827
• Locus Specific Databases
  • BLNKbase: Mutation registry for BLNK deficiency
  • LRG_21

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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