VHL/HRCA1 Antibody, ALEXA FLUOR 594

• Catalog number
  bs-1367R-A594
• Price
  Please ask
• Size
  100ul

• Long name
  VHL/HRCA1 Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
• Also known as
  Anti-VHL/HRCA1 PAb ALEXA FLUOR 594
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 594
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  VHL/HRCA1
• Specificity
  This is a highly specific antibody against VHL/HRCA1.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human VHL
• Gene ID Number
  7428
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq].
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  590nm/617nm
• Synonyms
  Von Hippel Lindau; von Hippel-Lindau syndrome protein homolog; Hippel-Lindau disease tumor suppressor VHL; von Hippel-Lindau tumor suppressor isoform 1; VHL; HRCA1; RCA1; VHL1; von Hippel-Lindau disease tumor suppressor isoform 2;pVHL; pVHL; G7 protein; Elongin binding protein; Protein G7; VHL 1; VHL_HUMAN;VHL1; VHLH; Von Hippel Lindau disease tumor suppressor; von Hippel Lindau syndrome; von Hippel Lindau tumor suppressor; Von Hippel-Lindau disease tumor suppressor.
• Properties
  For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• French translation
  anticorps

• Gene target
  VHL/HRCA1  
• Gene symbol
  VHL, RNF139
• Short name
  Anti-VHL/HRCA1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  VHL/HRCA1 Polyclonal Antibody, ALEXA FLUOR 594
• Alternative technique
  antibodies
• Alternative to gene target
  von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase, HRCA1 and pVHL and RCA1 and VHL1, VHL and IDBG-17819 and ENSG00000134086 and 7428, enzyme binding, nuclei, Vhl and IDBG-178105 and ENSMUSG00000033933 and 22346, BT.79817 and IDBG-644624 and ENSBTAG00000016101 and 540957

Gene info

• Identity
  HGNC:12687
• Gene
  VHL
• Long gene name
  von Hippel-Lindau tumor suppressor
• Synonyms gene name
  • von Hippel-Lindau syndrome
  • von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
• Synonyms
  • VHL1
• GenBank acession
  • L15409
• Locus
  3p25.3
• Discovery year
  1986-01-01
• Entrez gene record
  7428
• Pubmed identfication
  • 9671762
• RefSeq identity
  • NM_000551
• VEGA ID
  OTTHUMG00000128668
• Locus Specific Databases
  • UMD Locus Specific Databases
  • LRG_322

Gene info

• Identity
  HGNC:17023
• Gene
  RNF139
• Long gene name
  ring finger protein 139
• Synonyms
  • TRC8
  • RCA1
  • HRCA1
• Synonyms name
  • translocation in renal carcinoma, chromosome 8
• GenBank acession
  • AF064801
• Locus
  8q24.13
• Discovery year
  2003-05-21
• Entrez gene record
  11236
• Pubmed identfication
  • 9689122
• RefSeq identity
  • NM_007218
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000165072

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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