PANK2 Antibody, ALEXA FLUOR 350

• Catalog number
  bs-8338R-A350
• Price
  Please ask
• Size
  100ul

• Long name
  PANK2 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
• Also known as
  Anti-PANK2 PAb ALEXA FLUOR 350
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 350
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  PANK2
• Specificity
  This is a highly specific antibody against PANK2.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PANK2
• Gene ID Number
  80025
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Defects in PANK2 are the cause of neurodegeneration with brain iron accumulation type 1 (NBIA1); also known as pantothenate kinase-associated neurodegeneration (PKAN) or Hallervorden-Spatz syndrome (HSS). It is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. Clinical manifestations include progressive muscle spasticity, hyperreflexia, muscle rigidity, dystonia, dysarthria, and intellectual deterioration which progresses to severe dementia over several years. It is clinically classified into classic, atypical, and intermediate phenotypes. Classic forms present with onset in the first decade, rapid progression, loss of independent ambulation within 15 years. Atypical forms have onset in the second decade, slow progression, maintenance of independent ambulation up to 40 years later. Intermediate forms manifest onset in the first decade with slow progression or onset in the second decade with rapid progression. Patients with early onset tend to also develop pigmentary retinopathy, whereas those with later onset tend to also have speech disorders and psychiatric features. All patients have the 'eye of the tiger' sign on brain MRI.Defects in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP). HARP is a rare syndrome with many clinical similarities to NBIA1.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  343nm/442nm
• Synonyms
  C20orf48; HARP; hPANK2; HSS; MGC15053; NBIA1; PANK2; PANK2_HUMAN; Pantothenate kinase 2 Hallervorden Spatz syndrome; Pantothenate kinase 2; Pantothenic acid kinase 2; PKAN; RP23 387C21.4.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 350
• French translation
  anticorps

• Gene target
  PANK2  
• Gene symbol
  PANK2-AS1, PANK2
• Short name
  Anti-PANK2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 350
• Alternative name
  PANK2 Polyclonal Antibody, ALEXA FLUOR 350
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:40732
• Gene
  PANK2-AS1
• Long gene name
  PANK2 antisense RNA 1
• Locus
  20p13
• Discovery year
  2019-09-19
• Entrez gene record
  107985395
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:15894
• Gene
  PANK2
• Long gene name
  pantothenate kinase 2
• Synonyms gene
  • C20orf48
  • NBIA1
• Synonyms gene name
  • neurodegeneration with brain iron accumulation 1 (Hallervorden-Spatz syndrome)
• Synonyms
  • HSS
  • FLJ11729
  • PKAN
  • HARP
• Synonyms name
  • Hallervorden-Spatz syndrome
  • pantothenate kinase-associated neurodegeneration
• GenBank acession
  • AK021791
• Locus
  20p13
• Discovery year
  2001-06-21
• Entrez gene record
  80025
• Pubmed identfication
  • 8944032
  • 11479594
• RefSeq identity
  • NM_024960
• Classification
  • Pantothenate kinases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000031768
• Locus Specific Databases
  • LRG_1016

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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