P105 RB (Thr826) Antibody, ALEXA FLUOR 647

• Catalog number
  bs-5667R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  P105 RB (Thr826) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-P105 RB Thr826 PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  P105 RB Thr826
• Specificity
  This is a highly specific antibody against P105 RB Thr826.
• Modification
  Phosphorylation
• Modification Site
  Thr826
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human Retinoblastoma associated protein around the phosphorylation site of Thr826
• Gene ID Number
  5925
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  RB1phospho T826; OSRC; P105 RB; P105RB; PP105; PP110; pRb; RB 1; RB1; RB1 protein; Retinoblastoma 1 including osteosarcoma; Retinoblastoma 1; Retinoblastoma associated protein; Retinoblastoma related osteosarcoma; Retinoblastoma susceptibility gene; Including osteosarcoma; RB_HUMAN.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-P105 RB Thr826 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  P105   Thr826  
• Gene symbol
  NFKB2, SCYL1, NFKB1
• Short name
  Anti-P105 RB Thr826
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  P105 RB (Thr826) Polyclonal Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7795
• Gene
  NFKB2
• Long gene name
  nuclear factor kappa B subunit 2
• Synonyms gene name
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
• Synonyms
  • LYT-10
  • p52
  • p105
  • NF-kB2
  • p49/p100
• GenBank acession
  • X61498
• Locus
  10q24.32
• Discovery year
  1991-11-14
• Entrez gene record
  4791
• Pubmed identfication
  • 1876189
• Classification
  • IPT domain containing
  • NF-kappa B complex subunits
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000018962
• Locus Specific Databases
  • LRG_1347

Gene info

• Identity
  HGNC:14372
• Gene
  SCYL1
• Long gene name
  SCY1 like pseudokinase 1
• Synonyms gene
  • NTKL
• Synonyms gene name
  • N-terminal kinase-like
  • SCY1-like 1 (S. cerevisiae)
  • SCY1-like, kinase-like 1
• Synonyms
  • HT019
  • P105
  • GKLP
  • NKTL
  • TAPK
  • TRAP
  • TEIF
  • MGC78454
• Synonyms name
  • teratoma-associated tyrosine kinase
  • telomerase transcriptional elements-interacting factor
  • telomerase regulation-associated protein
• GenBank acession
  • AF225424
• Locus
  11q13.1
• Discovery year
  2001-01-16
• Entrez gene record
  57410
• Pubmed identfication
  • 11118629
• RefSeq identity
  • NM_020680
• Classification
  • Armadillo like helical domain containing
  • SCY1 like pseudokinases
• VEGA ID
  OTTHUMG00000166325

Gene info

• Identity
  HGNC:7794
• Gene
  NFKB1
• Long gene name
  nuclear factor kappa B subunit 1
• Synonyms gene name
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
• Synonyms
  • KBF1
  • p105
  • NFKB-p50
  • p50
  • NF-kappaB
  • NFkappaB
  • NF-kB1
• Synonyms name
  • Nuclear factor NF-kappa-B p105 subunit
• GenBank acession
  • M58603
• Locus
  4q24
• Discovery year
  1991-11-14
• Entrez gene record
  4790
• Pubmed identfication
  • 1992489
• RefSeq identity
  • NM_003998
• Classification
  • NF-kappa B complex subunits
  • Ankyrin repeat domain containing
  • IPT domain containing
• VEGA ID
  OTTHUMG00000161080
• Locus Specific Databases
  • LRG_1316

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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