Nucleophosmin Antibody, ALEXA FLUOR 647

• Catalog number
  bs-4757R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  Nucleophosmin Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-Nucleophosmin PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Nucleophosmin
• Specificity
  This is a highly specific antibody against Nucleophosmin.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  1-50/259
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Nucleophosmin
• Gene ID Number
  4869
• Swiss Prot
  P06748
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  B23; NPM; Nucleophosmin; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin; NPM1
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-Nucleophosmin exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  Nucleophosmin  
• Gene symbol
  NPM1P24, NPM1P41, NPM1P8
• Short name
  Anti-Nucleophosmin
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  Nucleophosmin Polyclonal Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:45097
• Gene
  NPM1P24
• Long gene name
  nucleophosmin 1 pseudogene 24
• Synonyms gene name
  • nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene
  • nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 24
• Locus
  10q22.1
• Discovery year
  2013-02-15
• Entrez gene record
  100422312
• RefSeq identity
  • NG_025446
• VEGA ID
  OTTHUMG00000018445

Gene info

• Identity
  HGNC:45220
• Gene
  NPM1P41
• Long gene name
  nucleophosmin 1 pseudogene 41
• Synonyms gene name
  • nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 41
• Locus
  4q21.22
• Discovery year
  2013-03-07
• Entrez gene record
  100422249
• RefSeq identity
  • NG_025136
• VEGA ID
  OTTHUMG00000160939

Gene info

• Identity
  HGNC:7928
• Gene
  NPM1P8
• Long gene name
  nucleophosmin 1 pseudogene 8
• Synonyms gene name
  • nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 8
• Locus
  Xp21.1
• Discovery year
  1999-05-28
• Entrez gene record
  100130233
• VEGA ID
  OTTHUMG00000021333

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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