MUC4 Antibody, ALEXA FLUOR 647

• Catalog number
  bs-4772R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  MUC4 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-MUC4 PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  MUC4
• Specificity
  This is a highly specific antibody against MUC4.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  1240-1290/2169
• Subcellular location
  Secreted, Cell membrane
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Mucin-4 alpha chain
• Gene ID Number
  4585
• Swiss Prot
  Q99102
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  ASGP; MUC-4; HSA276359; Mucin-4; Ascites sialoglycoprotein; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin; MUC4
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-MUC4 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  MUC4  
• Gene symbol
  MUC4
• Short name
  Anti-MUC4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  MUC4 Polyclonal Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies
• Alternative to gene target
  mucin 4, cell surface associated, ASGP and HSA276359 and MUC-4, MUC4 and IDBG-70699 and ENSG00000145113 and 4585, extracellular matrix constituent, Extracellular, Muc4 and IDBG-250337 and ENSMUSG00000079620 and 140474, MUC4 and IDBG-633795 and ENSBTAG00000014721 and

Gene info

• Identity
  HGNC:7514
• Gene
  MUC4
• Long gene name
  mucin 4, cell surface associated
• Synonyms gene name
  • mucin 4, tracheobronchial
• GenBank acession
  • AJ276359
• Locus
  3q29
• Discovery year
  1991-05-22
• Entrez gene record
  4585
• Pubmed identfication
  • 1673336
• RefSeq identity
  • NM_018406
• Classification
  • Mucins
• VEGA ID
  OTTHUMG00000151827

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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