MKK7/ERK7 Antibody, ALEXA FLUOR 488

• Catalog number
  bs-1979R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  MKK7/ERK7 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-MKK7/ERK7 PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  MKK7/ERK7
• Specificity
  This is a highly specific antibody against MKK7/ERK7.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  300-350/419
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MKK7
• Gene ID Number
  5609
• Swiss Prot
  O14733
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4; Dual specificity mitogen-activated protein kinase kinase 7; MAP kinase kinase 7; MAPKK 7; JNK-activating kinase 2; MAPK/ERK kinase 7; Stress-activated protein kinase kinase 4; SAPK kinase 4; c-Jun N-terminal kinase kinase 2; JNK kinase 2; JNKK 2; MAP2K7; MEK7; SKK4
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-MKK7/ERK7 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  MKK7/ERK7  
• Gene symbol
  MAPK15, MAP2K7
• Short name
  Anti-MKK7/ERK7
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  MKK7/ERK7 Polyclonal Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:24667
• Gene
  MAPK15
• Long gene name
  mitogen-activated protein kinase 15
• Synonyms
  • ERK8
  • ERK7
• Synonyms name
  • extracellular signal regulated kinase 8
• GenBank acession
  • AY065978
• Locus
  8q24.3
• Discovery year
  2005-04-05
• Entrez gene record
  225689
• Pubmed identfication
  • 11875070
• RefSeq identity
  • NM_139021
• Classification
  • Mitogen-activated protein kinases
• VEGA ID
  OTTHUMG00000146450

Gene info

• Identity
  HGNC:6847
• Gene
  MAP2K7
• Long gene name
  mitogen-activated protein kinase kinase 7
• Synonyms gene
  • PRKMK7
• Synonyms
  • MKK7
  • Jnkk2
• GenBank acession
  • AF006689
• Locus
  19p13.2
• Discovery year
  1998-04-28
• Entrez gene record
  5609
• Pubmed identfication
  • 9312068
• Classification
  • Mitogen-activated protein kinase kinases
• VEGA ID
  OTTHUMG00000137368

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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