LOX 1 Antibody, ALEXA FLUOR 594
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Catalog numberbs-2044R-A594
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PricePlease ask
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Size100ul
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Long nameLOX 1 Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
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Also known asAnti-LOX 1 PAb ALEXA FLUOR 594
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CategoryConjugated Primary Antibodies
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Conjugated withALEXA FLUOR® 594
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Host OrganismRabbit (Oryctolagus cuniculus)
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Target AntigenLOX 1
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SpecificityThis is a highly specific antibody against LOX 1.
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ModificationUnmodified
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Modification SiteNone
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ClonalityPolyclonal
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ClonePolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range224-274/274
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Subcellular locationExtracellular
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SourceKLH conjugated synthetic peptide derived from Rabbit LOX-1
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Gene ID Number100009322
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Swiss ProtQ9XTA8
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Tested applicationsIF(IHC-P)
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Recommended dilutionsIF(IHC-P)(1:50-200)
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CrossreactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigenReceptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity).
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PurificationPurified by Protein A.
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Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission590nm/617nm
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SynonymsLOX1; LOX-1; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; Lectin-like oxidized LDL receptor 1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1; OLR1
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PropertiesFor facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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ConjugationAlexa Fluor, ALEXA FLUOR® 594
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ConjugatedAlexa conjugate 1
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French translationanticorps
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Gene target
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Gene symbolLOX, ALOX5, ALOX12B, ALOX12, ALOX15, ALOX15B, ALOXE3, OLR1
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Short nameAnti-LOX 1
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeImmunoglobulin G (IgG)
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LabelALEXA FLUOR 594
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Alternative nameLOX 1 Polyclonal Antibody, ALEXA FLUOR 594
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namelysyl oxidase
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Synonyms name
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namearachidonate 5-lipoxygenase
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-07-10
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearachidonate 12-lipoxygenase, 12R type
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-07-22
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namearachidonate 12-lipoxygenase, 12S type
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Synonyms gene name
- arachidonate 12-lipoxygenase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-08-07
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearachidonate 15-lipoxygenase
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-11-20
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearachidonate 15-lipoxygenase type B
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Synonyms gene name
- arachidonate 15-lipoxygenase, second type
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-07-22
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearachidonate lipoxygenase 3
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-11-29
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameoxidized low density lipoprotein receptor 1
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Synonyms gene name
- oxidised low density lipoprotein (lectin-like) receptor 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-01-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C-type lectin domain containing
- Scavenger receptors
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
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Tree numbers
- E05.393.220
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Qualifiersdrug effects, methods, radiation effects