Glucocorticoid receptor Antibody, ALEXA FLUOR 647
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Catalog numberbs-0252R-A647
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PricePlease ask
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Size100ul
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Long nameGlucocorticoid receptor Antibody, ALEXA FLUOR 647 Conjugated
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Also known asAnti-Glucocorticoid receptor PAb ALEXA FLUOR 647
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CategoryConjugated Primary Antibodies
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Conjugated withALEXA FLUOR® 647
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Host OrganismRabbit (Oryctolagus cuniculus)
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Target AntigenGlucocorticoid receptor
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SpecificityThis is a highly specific antibody against Glucocorticoid receptor .
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ModificationUnmodified
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Modification SiteNone
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ClonalityPolyclonal
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ClonePolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range230-280/777
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Subcellular locationCytoplasm, Nucleus
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Glucocorticoid receptor
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Gene ID Number2908
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Swiss ProtP04150
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Tested applicationsFCM, IF(IHC-P)
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Recommended dilutionsFCM(1:20-100), IF(IHC-P)(1:50-200)
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CrossreactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigenReceptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.
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PurificationPurified by Protein A.
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Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission650nm/665nm
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SynonymsGR; GCR; GRL; GCCR; GCRST; Glucocorticoid receptor; Nuclear receptor subfamily 3 group C member 1; NR3C1
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PropertiesFor facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-Glucocorticoid receptor exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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ConjugationAlexa Fluor, ALEXA FLUOR 647
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DescriptionThe receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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French translationanticorps
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Gene target
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Gene symbolNR3C1, NCOA2, ARHGAP35
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Short nameAnti-Glucocorticoid receptor
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeImmunoglobulin G (IgG)
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LabelALEXA FLUOR 647
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Alternative nameGlucocorticoid receptor Antibody, ALEXA FLUOR 647
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namenuclear receptor subfamily 3 group C member 1
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Synonyms gene
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Synonyms gene name
- nuclear receptor subfamily 3, group C, member 1
- nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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Classification
- Nuclear receptor subfamily 3 group C
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namenuclear receptor coactivator 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-12-17
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Entrez gene record
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Pubmed identfication
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Classification
- Lysine acetyltransferases
- Basic helix-loop-helix proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRho GTPase activating protein 35
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Synonyms gene
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Synonyms gene name
- glucocorticoid receptor DNA binding factor 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-12-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Rho GTPase activating proteins
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
