Cubilin Antibody, ALEXA FLUOR 488

• Catalog number
  bs-3901R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  Cubilin Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-Cubilin PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Cubilin
• Specificity
  This is a highly specific antibody against Cubilin.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  50-90/3623
• Subcellular location
  Intracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Cubilin
• Gene ID Number
  8029
• Swiss Prot
  O60494
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  IFCR; MGA1; gp280; Cubilin; 460 kDa receptor; Intestinal intrinsic factor receptor; Intrinsic factor-cobalamin receptor; Intrinsic factor-vitamin B12 receptor; CUBN
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-Cubilin has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  Cubilin  
• Gene symbol
  CUBNP3, CUBN, CUBNP1
• Short name
  Anti-Cubilin
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  Cubilin Polyclonal Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:44985
• Gene
  CUBNP3
• Long gene name
  cubilin pseudogene 3
• Synonyms gene name
  • cubilin (intrinsic factor-cobalamin receptor) pseudogene 3
• Locus
  10q11.21
• Discovery year
  2013-01-03
• Entrez gene record
  100421634
• RefSeq identity
  • NG_025491
• VEGA ID
  OTTHUMG00000018073

Gene info

• Identity
  HGNC:2548
• Gene
  CUBN
• Long gene name
  cubilin
• Synonyms gene
  • MGA1
• Synonyms gene name
  • cubilin (intrinsic factor-cobalamin receptor)
• Synonyms
  • IFCR
  • gp280
• Synonyms name
  • intrinsic factor-cobalamin receptor
• GenBank acession
  • AF034611
• Locus
  10p13
• Discovery year
  1998-11-02
• Entrez gene record
  8029
• Pubmed identfication
  • 9572993
  • 9478979
• RefSeq identity
  • NM_001081
• VEGA ID
  OTTHUMG00000017741
• Locus Specific Databases
  • LRG_540

Gene info

• Identity
  HGNC:44983
• Gene
  CUBNP1
• Long gene name
  cubilin pseudogene 1
• Synonyms gene name
  • cubilin (intrinsic factor-cobalamin receptor) pseudogene 1
• Locus
  10q11.21
• Discovery year
  2013-01-03
• Entrez gene record
  728064
• RefSeq identity
  • NG_023216
• VEGA ID
  OTTHUMG00000018016

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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