CDKN2A (Ser140) Antibody, ALEXA FLUOR 647
-
Catalog numberbs-5253R-A647
-
PricePlease ask
-
Size100ul
-
-
Long nameCDKN2A (Ser140) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
-
Also known asAnti-CDKN2A Ser140 PAb ALEXA FLUOR 647
-
CategoryConjugated Primary Antibodies
-
Conjugated withALEXA FLUOR® 647
-
Host OrganismRabbit (Oryctolagus cuniculus)
-
Target AntigenCDKN2A Ser140
-
SpecificityThis is a highly specific antibody against CDKN2A Ser140.
-
ModificationPhosphorylation
-
Modification SiteSer140
-
ClonalityPolyclonal
-
ClonePolyclonal antibody
-
Concentration1ug per 1ul
-
SourceKLH conjugated synthetic phosphopeptide derived from human CDKN2A around the phosphorylation site of Ser140 [RG(p-S)NH]
-
Gene ID Number1029
-
Tested applicationsIF(IHC-P)
-
Recommended dilutionsIF(IHC-P)(1:50-200)
-
CrossreactivityHuman
-
Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the antigenThis gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].
-
PurificationPurified by Protein A.
-
Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
-
Excitation emission650nm/665nm
-
Synonymsp-CDKN2A/p16-INK4aSer140; p-p16-INK4aSer140; cyclin-dependent kinase inhibitor 2A;CDK4I; p16-INK4; p16-INK4a; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A, isoform 1; Cyclin dependent kinase inhibitor 2A p16, inhibits CDK4; cell cycle inhibitor; cyclin-dependent kinase inhibitor 2a p16Ink4a; cell cycle regulator; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 2; Cdkn2a; Arf; INK4A; MTS1; p16; p16Cdkn2a; p19ARF; CD2A1_HUMAN.
-
PropertiesFor facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-CDKN2A Ser140 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
ConjugationAlexa Fluor, ALEXA FLUOR 647
-
French translationanticorps
-
Gene target
-
Gene symbolCDKN2A-DT, CDKN2A
-
Short nameAnti-CDKN2A Ser140
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
IsotypeImmunoglobulin G (IgG)
-
LabelALEXA FLUOR 647
-
Alternative nameCDKN2A (Ser140) Polyclonal Antibody, ALEXA FLUOR 647
-
Alternative techniqueantibodies
-
Alternative to gene targetcyclin-dependent kinase inhibitor 2A, ARF and CDK4I and CDKN2 and CMM2 and INK4 and INK4A and MLM and MTS-1 and MTS1 and P14 and P14ARF and P16 and P16-INK4A and P16INK4 and P16INK4A and P19 and P19ARF and TP16, CDKN2A and IDBG-54547 and ENSG00000147889 and 1029, MDM2/MDM4 family protein binding, nuclei, CDKN2A and IDBG-630043 and ENSBTAG00000034220 and 616369
-
Gene info
-
Identity
-
Gene
-
Long gene nameCDKN2A divergent transcript
-
Synonyms gene
-
Synonyms gene name
- chromosome 9 open reading frame 53
- CDKN2A antisense RNA 1 (head to head)
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2004-07-23
-
Entrez gene record
-
RefSeq identity
-
Classification
- Divergent transcripts
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namecyclin dependent kinase inhibitor 2A
-
Synonyms gene
-
Synonyms gene name
- cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1994-05-19
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data