Anti-SMC1 (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-3568R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  SMC1
• Specificity
  This antibody reacts specifically with SMC1
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  Nucleus
• Antigen Source
  KLH conjugated synthetic peptide derived from human SMC1
• Gene ID
  8243
• Swiss Prot
  Q14683
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  SMC1; SMCB; CDLS2; SB1.8; SMC1L1; DXS423E; SMC1alpha; Structural maintenance of chromosomes protein 1A; SMC protein 1A; SMC-1-alpha; SMC-1A; SMC1A; KIAA0178
• Also known as
  SMC1 Polyclonal Antibody
• Other name
  Anti-SMC1 Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  SMC1  
• Gene symbol
  SMC1B, SMC1A
• Short name
  Anti-SMC1
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  SMC1 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:11112
• Gene
  SMC1B
• Long gene name
  structural maintenance of chromosomes 1B
• Synonyms gene
  • SMC1L2
• Synonyms gene name
  • SMC1 (structural maintenance of chromosomes 1, yeast)-like 1
  • SMC1 structural maintenance of chromosomes 1-like 2 (yeast)
• Synonyms
  • bK268H5
• GenBank acession
  • AJ504806
• Locus
  22q13.31
• Discovery year
  2000-01-12
• Entrez gene record
  27127
• Pubmed identfication
  • 10591208
  • 11564881
• RefSeq identity
  • NM_148674
• Classification
  • Structural maintenance of chromosomes proteins
  • Cohesin complex
• VEGA ID
  OTTHUMG00000151334

Gene info

• Identity
  HGNC:11111
• Gene
  SMC1A
• Long gene name
  structural maintenance of chromosomes 1A
• Synonyms gene
  • SMC1L1
• Synonyms gene name
  • SMC1 (structural maintenance of chromosomes 1, yeast)-like 1
  • SMC1 structural maintenance of chromosomes 1-like 1 (yeast)
• Synonyms
  • DXS423E
  • KIAA0178
  • SB1.8
  • Smcb
• GenBank acession
  • S78271
• Locus
  Xp11.22
• Discovery year
  2000-08-11
• Entrez gene record
  8243
• Pubmed identfication
  • 7757074
  • 17273969
• RefSeq identity
  • NM_006306
• Classification
  • Structural maintenance of chromosomes proteins
  • Cohesin complex
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000021614
• Locus Specific Databases
  • Global Variome shared LOVD
  • LOVD
  • Global Variome shared LOVD
  • LRG_773

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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