Recombinant Human Gamma-secretase subunit APH-1A (APH1a), partial

Estimated Turnaround Time

3-5 weeks
Gene Name

APH1a
Alternative Names

Aph-1alpha; Presenilin-stabilization factor
Source

in vitro E.coli expression system
Purity

> 90% by SDS-PAGE
Shipping Conditions

Ice packs
Storage conditions

Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.
Shelf life

12 months in lyophilized form; 6 months in solution form.
Restriction

For research use only. Not for diagnostic procedures.
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source

Recombinants or rec. proteins
Group

recombinants

Gene target

Gamma-secretase subunit APH-1A APH1a partial
Gene symbol

APH1A, IGHD1OR15-1A, UBP1, APH1B, MTNR1A, IGKV2OR2-1, SCLT1, HIF1A-AS1, HIF1A-AS2, MARK3
Short name

Recombinant Gamma-secretase subunit APH-1A (APH1a), partial
Technique

Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biomatik advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
Species

Homo sapiens (Human), Humans
Alternative name

Rec. H. sapiens g-secretase functionnal sequence APH-1A (anterior pharynx defective 1 homolog A (C. elegans)), partial
Alternative technique

rec
Alternative to gene target

anterior pharynx defective 1 homolog A (C. elegans), APH1A and IDBG-102071 and ENSG00000117362 and 51107, protein binding, Plasma membranes, Aph1a and IDBG-174034 and ENSMUSG00000015750 and 226548, APH1A and IDBG-633431 and ENSBTAG00000021482 and 539247

Identity

HGNC:29509
Gene

APH1A
Long gene name

aph-1 homolog A, gamma-secretase subunit
Synonyms gene name
- anterior pharynx defective 1 homolog A (C. elegans)
- APH1A gamma secretase subunit
Synonyms
- APH-1A
- CGI-78
GenBank acession
- AF151835
Locus

1q21.2
Discovery year

2005-02-08
Entrez gene record

51107
Pubmed identfication
- 10810093
- 12110170
RefSeq identity
- NM_016022
VEGA ID

OTTHUMG00000012545

Identity

HGNC:24080
Gene

APH1B
Long gene name

aph-1 homolog B, gamma-secretase subunit
Synonyms gene name
- anterior pharynx defective 1 homolog B (C. elegans)
- APH1B gamma secretase subunit
Synonyms
GenBank acession
- AY358698
Locus

15q22.2
Discovery year

2005-02-08
Entrez gene record

83464
Pubmed identfication
- 12110170
- 11230166
RefSeq identity
- NM_031301
VEGA ID

OTTHUMG00000132863

Identity

HGNC:5805
Gene

IGKV2OR2-1
Long gene name

immunoglobulin kappa variable 2/OR2-1 (pseudogene)
Synonyms gene
- IGKV2OR2-1A
Synonyms gene name
- immunoglobulin kappa variable 2/OR2-1
- immunoglobulin kappa variable 2/OR2-1 pseudogene
Synonyms
- IGKV2/OR2-1
- IGKV2/OR2-1A
GenBank acession
- X05101
Locus

2q11.2
Discovery year

2000-04-18
Entrez gene record

28861
Pubmed identfication
- 8011175
Classification
- Immunoglobulin kappa (IGK) orphons
VEGA ID

OTTHUMG00000155332

Name

Primary Cell Culture
Concept

Scope note: The initial culturing of cells derived directly from fresh TISSUES.
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data