Recombinant Activin Receptor Like Kinase 1 (ALK1)

Estimated Turnaround Time

6-11 business days
Gene Name

NA
Alternative Names

ACVRL1; ACVRLK1; HHT2; ORW2; SKR3; TSR-I; TGF-B superfamily receptor type I; Activin A Receptor Type II-Like 1; Serine/Threonine-Protein Kinase Receptor R3
Source

E.coli
Purity

> 95%
Application

Positive Control; Immunogen; SDS-PAGE; WB.
Shipping Conditions

Ice packs
Storage conditions

Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.
Shelf life

1 year
Restriction

For research use only. Not for diagnostic procedures.
Description

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
Additional source

Recombinants or rec. proteins
Group

recombinants

Gene target

Activin Receptor Like Kinase ALK1
Gene symbol

ALK, ACVRL1, SLPI
Short name

Recombinant Activin Receptor Like Kinase 1 (ALK1)
Technique

Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biomatik advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
Species

Homo sapiens (Human)
Alternative name

Rec. Activin Receptor Like phosphorylation catalyst 1 (ALK1)
Alternative technique

rec

Identity

HGNC:427
Gene

ALK
Long gene name

ALK receptor tyrosine kinase
Synonyms gene name
- anaplastic lymphoma kinase (Ki-1)
- anaplastic lymphoma receptor tyrosine kinase
Synonyms
- CD246
- ALK1
GenBank acession
- D45915
Locus

2p23.2-p23.1
Discovery year

1993-08-24
Entrez gene record

238
Pubmed identfication
- 8122112
RefSeq identity
- NM_004304
Classification
- Receptor tyrosine kinases
- CD molecules
VEGA ID

OTTHUMG00000152034
Locus Specific Databases
- LRG_488

Identity

HGNC:175
Gene

ACVRL1
Long gene name

activin A receptor like type 1
Synonyms gene
- ACVRLK1
- ORW2
Synonyms gene name
- activin A receptor type II-like 1
- activin A receptor type IL
Synonyms
- HHT2
- ALK1
- HHT
Synonyms name
- activin receptor-like kinase 1
GenBank acession
- L17075
Locus

12q13.13
Discovery year

1994-12-12
Entrez gene record

94
Pubmed identfication
- 8397373
- 8640225
- 22718755
RefSeq identity
- NM_000020
Classification
- Type 1 receptor serine/threonine kinases
VEGA ID

OTTHUMG00000169507
Locus Specific Databases
- Hereditary Hemorrhagic Telangiectasia (HHT) Mutation Database
- LRG_543

Identity

HGNC:11092
Gene

SLPI
Long gene name

secretory leukocyte peptidase inhibitor
Synonyms gene name
- secretory leukocyte protease inhibitor (antileukoproteinase)
Synonyms
- HUSI-I
- ALK1
- ALP
- BLPI
- HUSI
- WAP4
- WFDC4
Synonyms name
- antileukoproteinase
GenBank acession
- X04502
Locus

20q13.12
Discovery year

1998-04-24
Entrez gene record

6590
Pubmed identfication
- 3640338
- 12206714
Classification
- WAP four-disulfide core domain containing
VEGA ID

OTTHUMG00000033075

Name

Primary Cell Culture
Concept

Scope note: The initial culturing of cells derived directly from fresh TISSUES.
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data