Recombinant Human Thyroid hormone receptor beta(THRB)

• Catalog number
  RPC20095
• Price
  Please ask
• Size
  500 μg

• Verified reactivity
  Homo sapiens (Human)
• Protein number
  P10828
• Gene number
  THRB
• Other name
  Nuclear receptor subfamily 1 group A member 2c-erbA-2c-erbA-beta
• Protein origin
  E.coli
• Protein region
  1-461aa
• Protein sequence
  MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
• Information about sequence
  Full Length
• Expected molecular weight
  68.75kDa
• Protein purity
  ≥ 90%
• Storage recommendation
  Aliquot and store at -20°C. Minimize freezing and thawing.
• Use before
  1 year
• Shipping requirements
  Blue ice
• Estimated production time
  7-11 business days
• Notes
  For research use only. Not for diagnostic procedures.
• Hyperlink
• Description
  Hormone releasing factors and releasing hormones are  signaling molecules produced by glands in multicellular organisms. The glands that secrete Luteinizing hormones LHRG and LH, FSH comprise the endocrine signaling system. The term growth hormone releasing hormone GHRH is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or intracrine signaling) or nearby cells (paracrine signaling). Human recombinant LHRG and GHRH are produced in E. coli or in yeast cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Thyroid   hormone   receptor   beta   THRB  
• Gene symbol
  THRB-AS2, THRB-IT1, THRB-AS1, THRB
• Short name
  Recombinant Thyroid hormone receptor beta(THRB)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. bioma advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Label
  N-terminal 6xHis-SUMO-tagged
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Thyroid hormone receptor b(thyroid hormone receptor, b)
• Alternative technique
  rec
• Alternative to gene target
  thyroid hormone receptor, beta, C-ERBA-2 and C-ERBA-BETA and ERBA2 and GRTH and NR1A2 and PRTH and THR1 and THRB1 and THRB2, THRB and IDBG-22332 and ENSG00000151090 and 7068, thyroid hormone binding, nuclei, Thrb and IDBG-133569 and ENSMUSG00000021779 and 21834, THRB and IDBG-630420 and ENSBTAG00000017802 and 788329
• Tissue
  thyroid

Gene info

• Identity
  HGNC:54854
• Gene
  THRB-AS2
• Long gene name
  THRB antisense RNA 2
• Locus
  3p24.2
• Discovery year
  2020-02-28
• Entrez gene record
  101927854
• Pubmed identfication
  • 32087271
• RefSeq identity
  • NR_121667
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:41390
• Gene
  THRB-IT1
• Long gene name
  THRB intronic transcript 1
• Synonyms gene name
  • THRB intronic transcript 1 (non-protein coding)
• Locus
  3p24.2
• Discovery year
  2011-05-19
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000155680

Gene info

• Identity
  HGNC:44515
• Gene
  THRB-AS1
• Long gene name
  THRB antisense RNA 1
• Locus
  3p24.2
• Discovery year
  2012-11-14
• Entrez gene record
  644990
• RefSeq identity
  • NR_046244
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000155683

Gene info

• Identity
  HGNC:11799
• Gene
  THRB
• Long gene name
  thyroid hormone receptor beta
• Synonyms gene
  • ERBA2
  • PRTH
• Synonyms gene name
  • thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2)
  • pituitary resistance to thyroid hormone
  • thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
  • thyroid hormone receptor, beta
• Synonyms
  • THRB1
  • THRB2
  • NR1A2
  • THR1
  • ERBA-BETA
  • GRTH
  • TRbeta
• Synonyms name
  • avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2
  • oncogene ERBA2
  • generalized resistance to thyroid hormone
  • thyroid hormone receptor beta 1
• Locus
  3p24.2
• Discovery year
  1988-08-31
• Entrez gene record
  7068
• Pubmed identfication
  • 1973914
  • 8040303
• RefSeq identity
  • NM_000461
• Classification
  • Thyroid hormone receptors
• VEGA ID
  OTTHUMG00000130478

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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