PSEN1 Polyclonal Antibody

• Catalog number
  CAC07620
• Price
  Please ask
• Size
  50 μg

• Other name
  Presenilin-1,Protein S182,Presenilin-1 NTF subunit,Presenilin-1 CTF subunit,Presenilin-1 C,PSEN1,AD3,PS1,PSNL1
• Immunogen
  Recombinant human Presenilin-1 protein (4-218AA)
• Verified reactivity
  Human
• Verified applications
  ELISA,WB,IHC. Recommended dilution:WB:1:2000-1:5000,IHC:1:20-1:200
• Raised in
  Rabbit
• Clonality
  Polyclonal
• Protein number
  P49768
• Gene number
  Please refer to GenBank
• NCBI number
  Please refer to NCBI
• Purity
  Protein G purified, >95%
• Storage recommendation
  Aliquot and store at -20°C. Minimize freezing and thawing.
• Use before
  1 year
• Shipping requirements
  Blue ice
• Estimated production time
  3-7 business days
• Supplementary information
  Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
• Notes
  For research use only. Not for diagnostic procedures.
• Hyperlink
• Properties
  If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
• French translation
  anticorps

• Gene target
  PSEN1  
• Gene symbol
  PSEN1
• Short name
  PSEN1 Polyclonal Antibody
• Technique
  Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Label
  Unconjugated
• Alternative name
  presenilin 1 polyclonal (antibody to-)
• Alternative technique
  polyclonals, antibodies
• Alternative to gene target
  presenilin 1, AD3 and FAD and PS-1 and PS1 and S182, PSEN1 and IDBG-11235 and ENSG00000080815 and 5663, cadherin binding, nuclei, Psen1 and IDBG-155522 and ENSMUSG00000019969 and 19164, PSEN1 and IDBG-646832 and ENSBTAG00000011757 and 282705

Gene info

• Identity
  HGNC:9508
• Gene
  PSEN1
• Long gene name
  presenilin 1
• Synonyms gene
  • AD3
• Synonyms gene name
  • Alzheimer disease 3
• Synonyms
  • FAD
  • S182
  • PS1
• GenBank acession
  • AJ008005
• Locus
  14q24.2
• Discovery year
  1992-11-05
• Entrez gene record
  5663
• Pubmed identfication
  • 1411576
• RefSeq identity
  • NM_000021
• Classification
  • Peptidase family A22
• VEGA ID
  OTTHUMG00000141279
• Locus Specific Databases
  • Alzheimer Disease & Frontotemporal Dementia Mutation Database
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_224

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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