alpha-1 antitrypsin fragment

• Catalog number
  A1051-5
• Price
  Please ask
• Size
  5mg

• Description
  Alpha-1 antitrypsin (A1AT), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily. A1AT is produced mainly by the liver, but also by extrahepatic cells, including neutrophils and certain cancer cells. It is an acute phase protein and its concentration rises up to 3–4-fold above normal during acute inflammation.
• Similar products
• Formula
  C79H130N22O26
• Molecular Weight
  1804.01
• Additional description
  The alpha-1 antitrypsin is a α- or alpha protein sometimes glycoprotein present in blood.

• Gene target
  alpha-1   antitrypsin  
• Gene symbol
  SERPINA1, SERPINA2, SERPINA7
• Short name
  alpha-1 antitrypsin
• Isotype
  Antibody fragments and scFv fragments, single chain variable fragments can be E. coli expressed. Fragment peptides for polyclonals give monoclonal like antibodies as the epitope is very small. IgG Fc and(ab)2 fragments are small and stable subunits of the antibody obtained by enzymatic digestion. Complement fragments, bp DNA fragments are common.
• Alternative name
  a-1 antitrypsin fragment

Gene info

• Identity
  HGNC:8941
• Gene
  SERPINA1
• Long gene name
  serpin family A member 1
• Synonyms gene
  • PI
• Synonyms gene name
  • serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
• Synonyms
  • AAT
  • A1A
  • PI1
  • alpha-1-antitrypsin
  • A1AT
  • alpha1AT
• Synonyms name
  • protease inhibitor 1
  • anti-elastase
  • alpha-1 antitrypsin
  • alpha-1 proteinase inhibitor
• GenBank acession
  • X01683
• Locus
  14q32.13
• Discovery year
  1986-01-01
• Entrez gene record
  5265
• Pubmed identfication
  • 24172014
• RefSeq identity
  • NM_001002235
• Classification
  • Serpin peptidase inhibitors
• VEGA ID
  OTTHUMG00000150355
• Locus Specific Databases
  • LRG_575

Gene info

• Identity
  HGNC:8985
• Gene
  SERPINA2
• Long gene name
  serpin family A member 2 (gene/pseudogene)
• Synonyms gene
  • PIL
  • SERPINA2P
• Synonyms gene name
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2, pseudogene
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene)
• Synonyms
  • ATR
  • ARGS
• Synonyms name
  • protease inhibitor 1 (alpha-1-antitrypsin)-like
  • alpha-1 antitrypsin-related protein
• GenBank acession
  • JX680599
• Locus
  14q32.13
• Discovery year
  2001-06-22
• Entrez gene record
  390502
• Pubmed identfication
  • 15014966
  • 23826168
  • 24172014
• RefSeq identity
  • NM_006220
• Classification
  • Serpin peptidase inhibitors
• VEGA ID
  OTTHUMG00000171347

Gene info

• Identity
  HGNC:11583
• Gene
  SERPINA7
• Long gene name
  serpin family A member 7
• Synonyms gene
  • TBG
• Synonyms gene name
  • serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
• Synonyms name
  • thyroxin-binding globulin
  • thyroxine-binding globulin
  • alpha-1 antiproteinase, antitrypsin
• GenBank acession
  • M14091
• Locus
  Xq22.3
• Discovery year
  1986-01-01
• Entrez gene record
  6906
• Pubmed identfication
  • 24172014
• RefSeq identity
  • NM_000354
• Classification
  • Serpin peptidase inhibitors
• VEGA ID
  OTTHUMG00000022144
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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