PRO1, Profilin-1

• Catalog number
  AS16 3210
• Price
  Please ask
• Size
  100 µg

• Available ordering format
  Liquid in 0.1M PBS, pH 7.4, with 0.15M Sodium Chloride, and 0.05% Sodium Azide
• Immunogen
  Profilin 1 (PRF1) from Arabidopsis thaliana
• Raised in
  Mouse
• Clonality
  Monoclonal
• Clone
  IgG2a, clone mAbPRF1a (2-14D9)
• Purification
  Total IgG purified on a protein G column
• How to reconstitute
  See included datasheet or contact our support service
• Storage condition
  Store at -20°C.Make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
• Verified applications
  Immunohistochemistry (IHC), Western blot (WB)
• Connected products
  Plant and algal protein extraction bufferSecondary antibodies
• Recommended dilutions for use
  see datasheet
• Molecular weight expected аpparent
  14 kDa
• Verified reactivity
  Arabidopsis thaliana
• Possible reactivity
  to be determined
• No reactivity
  no confirmed exceptions from predicted reactivity are currently known
• Supplementary information
  This antibody reacts with PRF1.
• References
  Kandasamy, M.K., et al. (2002). Plant profilin isovariants are distinctly regulated in vegetative and reproductive tissues. Cell Motil Cytoskeleton 52(1):22-32. McKinney, E.C., et al. (2001) Small changes in the regulation of one Arabidopsis profilin isovariant, PRF1, alter seedling development. Plant Cell 13(5): 1179-91.
• Scientific context
  Profilin is an actin monomer-binding protein, involved in the organization and reconstruction of the actin cytoskeleton in eukaryotes. Profilin also interacts with membrane polyphospho-inositides, the Arp 2/3 complex, short proline rich stretches, and other ligands.
• Notes
  Exact working dilution needs to be determined by end user.
• Protein number
  Q42449
• TAIR number
  At2g19760
• Hyperlink

• Gene target
  PRO1   Profilin-1  
• Gene symbol
  LMNA, ZMPSTE24
• Short name
  PRO1, Profilin-1
• Alternative name
  PRO1, Profilin-1

Gene info

• Identity
  HGNC:6636
• Gene
  LMNA
• Long gene name
  lamin A/C
• Synonyms gene
  • LMN1
  • CMD1A
  • LGMD1B
  • PRO1
  • LMNL1
• Synonyms gene name
  • cardiomyopathy, dilated 1A (autosomal dominant)
  • limb girdle muscular dystrophy 1B (autosomal dominant)
  • progeria 1 (Hutchinson-Gilford type)
  • lamin A/C-like 1
• Synonyms
  • HGPS
  • MADA
• Synonyms name
  • mandibuloacral dysplasia type A
• GenBank acession
  • BC014507
• Locus
  1q22
• Discovery year
  1992-04-09
• Entrez gene record
  4000
• Pubmed identfication
  • 8511676
  • 8838815
  • 12702809
• RefSeq identity
  • NM_170707
• Classification
  • Lamins
• VEGA ID
  OTTHUMG00000013961
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • Leiden Muscular Dystrophy Pages
  • UMD Locus Specific Databases
  • Leiden Muscular Dystrophy pages
  • LRG_254

Gene info

• Identity
  HGNC:12877
• Gene
  ZMPSTE24
• Long gene name
  zinc metallopeptidase STE24
• Synonyms gene name
  • zinc metalloproteinase (STE24 homolog, yeast)
  • zinc metallopeptidase (STE24 homolog, yeast)
  • zinc metallopeptidase STE24 homolog (S. cerevisiae)
• Synonyms
  • FACE-1
  • Ste24p
  • STE24
  • HGPS
  • PRO1
• Synonyms name
  • Hutchinson-Gilford progeria syndrome
  • CAAX prenyl protease 1 homolog
• GenBank acession
  • Y13834
• Locus
  1p34.2
• Discovery year
  1999-09-17
• Entrez gene record
  10269
• Pubmed identfication
  • 10373325
  • 9700155
  • 16671095
• Classification
  • M48 metallopeptidase family
• VEGA ID
  OTTHUMG00000005762
• Locus Specific Databases
  • ZMPSTE24 @ LOVD
  • Leiden Muscular Dystrophy pages
  • LRG_212

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