HER2, Receptor tyrosine-protein kinase erbB-2

• Catalog number
  AS10 1579
• Price
  Please ask
• Size
  0.2 mg

• Available ordering format
  Liquid in 0.9% NaCl, 0.02% sodium azide
• Immunogen
  KLH-conjugated synthetic peptide: TFKGT PTAENPEYLG LDVPV, corresponding to C-terminal of human HER2. Accesion number P04626.
• Raised in
  Chicken
• Clonality
  Polyclonal
• Clone
  Polyclonal
• Purification
  Total IgY
• How to reconstitute
  See included datasheet or contact our support service
• Storage condition
  4 to 8°C
• Verified applications
  direct ELISA (ELISA)
• Connected products
  secondary antibodies
• Recommended dilutions for use
  1:2000 (ELISA)
• Molecular weight expected аpparent
  137.9 kDa
• Verified reactivity
  human
• Possible reactivity
  pig, horse, dog, panda
• No reactivity
  no confirmed exceptions from predicted reactivity known at the moment
• Supplementary information
  to be added when available
• References
  to be added when available
• Scientific context
  HER2 | Receptor tyrosine-protein kinase erbB-2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Defects in ERBB-2 are associated to various cancer forms.Synonymes: Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD_antigen=CD340
• Notes
  None
• Protein number
  P04626
• TAIR number
  Refer to NCBI
• Hyperlink
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  HER2   Receptor   tyrosine-protein   kinase   erbB-2  
• Gene symbol
  ERBB2
• Short name
  HER2, Receptor tyrosine-protein kinase erbB-2
• Alternative name
  HER2, Receptor tyrosine-protein phosphorylation catalyst erbB-2

Gene info

• Identity
  HGNC:3430
• Gene
  ERBB2
• Long gene name
  erb-b2 receptor tyrosine kinase 2
• Synonyms gene
  • NGL
• Synonyms gene name
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
• Synonyms
  • NEU
  • HER-2
  • CD340
  • HER2
• Synonyms name
  • neuro/glioblastoma derived oncogene homolog
  • human epidermal growth factor receptor 2
• GenBank acession
  • X03363
• Locus
  17q12
• Discovery year
  2001-06-22
• Entrez gene record
  2064
• RefSeq identity
  • NM_004448
• Classification
  • Erb-b2 receptor tyrosine kinases
  • CD molecules
  • Minor histocompatibility antigens
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000179300
• Locus Specific Databases
  • LRG_724

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