Abeta (1-42), Amyloid-beta peptide 1-42

• Catalog number
  AS08 328
• Price
  Please ask
• Size
  100 µl

• Available ordering format
  Lyophilized
• Immunogen
  synthetic peptide chosen from human Abeta (1-42) protein. Amino acid sequence: D-A-E-F-R-H-D-S-G-Y-E-V-H-H-Q-K-L-V-F-F-A-E-D-V-G-S-N-K-G-A-I-I-G-L-M-V-G-G-V-V-I-A
• Raised in
  Rabbit
• Clonality
  Polyclonal
• Clone
  Polyclonal
• Purification
  Serum
• How to reconstitute
  For reconstitution add 100 µl of sterile water.
• Storage condition
  store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
• Verified applications
  ELISA (ELISA), Dot Blot (Dot), immunolocalization (IL), Western blot (WB)
• Connected products
  Alzheimer | available antibodies for Alzheimer's disease
• Recommended dilutions for use
  1:1000 (DB), 1:3000 (ELISA), 1-2 µg/ml (IL)
• Molecular weight expected аpparent
  4.5 kDa
• Verified reactivity
  human
• Possible reactivity
  bovine, chicken, dog, porcine, rabbit
• No reactivity
  no confirmed exceptions from predicted reactivity known in the moment
• Supplementary information
  the antibody can detect Abeta (1-42), Abeta (1-28) Abeta (1-20) and Abeta (1-17). This product exhibits a low reactivity to monomeric Abeta (1-42) as determined by SDS-PAGE and Western blotting.Immunolocalization: human tissue was paraffin-embedded and sectioned. De-waxed and rehydrated in an ethanol gradient. Antigens were retrieved in sodium citrate buffer (pH 6) at 95°C for 1 h. The tissue sections were separately incubated for 1 h at RT with primary antibody and antibody binding was visualized with IgG Preoxidase Reagent Kit.
• References
  Lindhagen-Persson et al. (2010). Amyloid-β oligomer specificity mediated by the IgM isotype--implications for a specific protective mechanism exerted by endogenous auto-antibodies. PLoS One. 2010 Nov 10;5(11):e13928. doi: 10.1371/journal.pone.0013928.
• Scientific context
  Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-beta (Abeta), a peptide of 39-42 amino acids generated in vivo by specific, proteolytic cleavage of the amyloid precursor protein P05067
• Notes
  None
• Protein number
  Refer to NCBI
• TAIR number
  Refer to NCBI
• Hyperlink
• Description
  Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.

• Gene target
  Abeta   1-42   Amyloid-beta   peptide   1-42  
• Gene symbol
  SNORD115-42, IGLVI-42, IGKV1D-42, IGHV3-42, RNU6-42P, DSCAM, NFX1, KIR2DL1, IGHVII-1-1, MIR1-1
• Short name
  Abeta (1-42), Amyloid-beta peptide 1-42
• Technique
  peptide, peptides
• Alternative name
  Abeta (1-42), Amyloid-b short protein sequence 1-42
• Alternative technique
  peptides

Gene info

• Identity
  HGNC:33061
• Gene
  SNORD115-42
• Long gene name
  small nucleolar RNA, C/D box 115-42
• Synonyms
  • HBII-52-42
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033816
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003357.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5936
• Gene
  IGLVI-42
• Long gene name
  immunoglobulin lambda variable (I)-42 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable (I)-42
  • immunoglobulin lambda variable (I)-42 pseudogene
• Synonyms
  • IGLV(I)-42
• GenBank acession
  • X14613
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28767
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151043

Gene info

• Identity
  HGNC:5757
• Gene
  IGKV1D-42
• Long gene name
  immunoglobulin kappa variable 1D-42 (non-functional)
• Synonyms gene name
  • immunoglobulin kappa variable 1D-42
• GenBank acession
  • X72816
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28892
• RefSeq identity
  • NG_000833
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151573

Gene info

• Identity
  HGNC:5603
• Gene
  IGHV3-42
• Long gene name
  immunoglobulin heavy variable 3-42 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable 3-42
  • immunoglobulin heavy variable 3-42 pseudogene
• GenBank acession
  • M99671
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28427
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152081

Gene info

• Identity
  HGNC:34286
• Gene
  RNU6-42P
• Long gene name
  RNA, U6 small nuclear 42, pseudogene
• Synonyms gene
  • RNU6-42
• Synonyms gene name
  • RNA, U6 small nuclear 42
• Locus
  3q29
• Discovery year
  2008-06-10
• Entrez gene record
  100302742
• RefSeq identity
  • NR_028373

Gene info

• Identity
  HGNC:3039
• Gene
  DSCAM
• Long gene name
  DS cell adhesion molecule
• Synonyms gene name
  • Down syndrome cell adhesion molecule
• Synonyms
  • CHD2-42
  • CHD2-52
• GenBank acession
  • AF023449
• Locus
  21q22.2
• Discovery year
  1998-06-10
• Entrez gene record
  1826
• Pubmed identfication
  • 9426258
• RefSeq identity
  • NM_001389
• Classification
  • Ig-like cell adhesion molecule family
  • I-set domain containing
  • Fibronectin type III domain containing
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000086732

Gene info

• Identity
  HGNC:7803
• Gene
  NFX1
• Long gene name
  nuclear transcription factor, X-box binding 1
• Synonyms
  • NFX2
  • MGC20369
  • Tex42
  • TEG-42
• GenBank acession
  • U19759
• Locus
  9p12
• Discovery year
  1998-05-26
• Pubmed identfication
  • 7964459
  • 2511169
  • 12047746
• Classification
  • PHD finger proteins
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000019772

Gene info

• Identity
  HGNC:6329
• Gene
  KIR2DL1
• Long gene name
  killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
• Synonyms gene name
  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
• Synonyms
  • cl-42
  • nkat1
  • 47.11
  • p58.1
  • CD158A
• GenBank acession
  • L41267
• Locus
  19q13.42
• Discovery year
  1997-11-14
• Entrez gene record
  3802
• Pubmed identfication
  • 7749980
  • 7716543
• RefSeq identity
  • NM_014218
• Classification
  • Killer cell immunoglobulin like receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000065885
• Locus Specific Databases
  • IPD-KIR Database

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

Similar products