Caspase-1 Antibody

• Catalog number
  3019-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  Caspase-1
• Target Alternative Name
  CASP1, IL1BCE, P45, Interleukin-1 beta convertase, IL-1BC, IL1BC, p45, IL1B-convertase, CASP-1, ICE
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse, rat
• Immunogen Sequence
  Synthetic peptide surrounding amino acid 132 of human caspase-1
• Accession
  NP_150636
• Gene Id
  834
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.5 mg/ml
• Formulation
  In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.5 mM EDTA, 0.03% ProClin®
• Purification
  Affinity purified
• Application
  Western blot, Immunoprecipitation, Immunofluorescence
• Application And Usages
  Western blot analysis (0.5-4 µg/ml), immunoprecipitation (4-8 µg/ml) and immunofluorescence (10-20 µg/ml). The immunoaffinity purified antibody recognizes 45 kDa procaspase-1 and the 20 kDa cleaved product.
• Description
  Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-1 (ICE, interleukin-1β-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1β and IL-18 into active cytokines. Like other caspases, Caspase-1 itself is synthesized as a pro-enzyme that is cleaved during activation into a large (20 kDa) and small (10 kDa) subunits. The cellular role of caspase-1 appears limited to cytokine activation as they do not have obvious roles in apoptosis.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Additional description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
• French translation
  anticorps

• Gene target
  Caspase-1  
• Gene symbol
  CASP12, CASP1P3, CASP1
• Short name
  Caspase-1 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  caspase-1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:19004
• Gene
  CASP12
• Long gene name
  caspase 12 (gene/pseudogene)
• Synonyms gene
  • CASP12P1
• Synonyms gene name
  • caspase 12 pseudogene 1
  • caspase 12
• GenBank acession
  • AF464191
• Locus
  11q22.3
• Discovery year
  2002-07-25
• Entrez gene record
  100506742
• Pubmed identfication
  • 12054529
  • 9038361
  • 16917906
  • 16532395
• RefSeq identity
  • NM_001191016
• Classification
  • Caspases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000154965

Gene info

• Identity
  HGNC:43777
• Gene
  CASP1P3
• Long gene name
  caspase 1 pseudogene 3
• Synonyms gene name
  • caspase 1, apoptosis-related cysteine peptidase pseudogene 3
• Locus
  11q22.3
• Discovery year
  2012-02-24
• Entrez gene record
  100422634
• RefSeq identity
  • NG_024409

Gene info

• Identity
  HGNC:1499
• Gene
  CASP1
• Long gene name
  caspase 1
• Synonyms gene
  • IL1BC
• Synonyms gene name
  • caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
  • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
  • caspase 1, apoptosis-related cysteine peptidase
• Synonyms
  • ICE
• Synonyms name
  • caspase-1
  • interleukin 1, beta, convertase
• GenBank acession
  • U13697
• Locus
  11q22.3
• Discovery year
  1992-05-07
• Entrez gene record
  834
• Pubmed identfication
  • 1373520
  • 9250871
• RefSeq identity
  • NM_033292
• Classification
  • Caspases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000048072

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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