MIP-1 beta Recombinant Protein

• Catalog number
  40-407
• Price
  Please ask
• Size
  0.005 mg, 0.02 mg

• About recombinant protein
  Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant rat MIP-1 beta is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
• Other name of the recombinant
  ACT2, G-26, HC21, LAG1, LAG-1, MIP1B, SCYA2, SCYA4, MIP1B1, AT744.1, MIP-1-beta, C-C motif chemokine 4, G-26 T-lymphocyte-secreted protein
• Recombinant in
  E. coli
• SEQUENCE
  APIGSDPPTS CCFSYTSRKI HRNFVMDYYE TSSLCSQPAV VFLTKKGRQI CADPSEPWVN EYVNDLELN
• Activity
  Biological activity was determined by its ability to chemoattract human monocytes using a concentration range of 0.01 - 1.0 μg/mL.
• Keep at
  The lyophilized MIP-1 beta recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted MIP-1 beta is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing MIP-1 beta recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  4506845
• Accession nr
  NP_002975.1
• Pureity
  Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• About
  This product is for research use only.
• Protein s origin
  Rat
• Vial
  Lyophilized
• NCBI ID
  6351
• Gene name
  chemokine (C-C motif) ligand 4
• Source
  Homo sapiens
• Uniprot
  P13236
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  MIP-1   beta   Protein  
• Gene symbol
  CCL4
• Short name
  MIP-1 beta Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  MIP-1 b Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:10630
• Gene
  CCL4
• Long gene name
  C-C motif chemokine ligand 4
• Synonyms gene
  • LAG1
  • SCYA4
• Synonyms gene name
  • small inducible cytokine A4 (homologous to mouse Mip-1b)
  • chemokine (C-C motif) ligand 4
• Synonyms
  • MIP-1-beta
  • Act-2
  • AT744.1
• GenBank acession
  • M23502
• Locus
  17q12
• Discovery year
  1990-07-05
• Entrez gene record
  6351
• Pubmed identfication
  • 1972563
• RefSeq identity
  • NM_002984
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000188414

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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