MIA-2, human recombinant

• Catalog number
  4888-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  Melanoma inhibitory activity protein 2
• Alternative_names
  Melanoma inhibitory activity protein 2, Melanoma inhibitory activity protein 2
• Description
  Potential role in the pathophysiology of liver disease
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥97%
• Assay
  SDS-PAGE
• Purity
  ≥97%
• Molecular Weight
  11.5 kDa
• Storage Temp
  -20°C
• Shipping
  Blue ice
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Sterile filtered white powder lyophilized from a solution containing 20 mM phosphate buffer pH 7.4 and 150 mM NaCl.
• Reconstitution Instructions
  Reconstitute in sterile H₂O at >100 µg/ml. Reconstituted MIA2 should be stored in working aliquots at -20°C.
• Background Information
  MIA2 performs as a tumour suppressor in hepatocellular carcinoma. MIA2 is a novel acute phase protein which its expression is found in the liver and reacts to liver damage in chronic liver diseases and is considerably higher in severe fibrosis patients . MIA2 is induced by IL6, TGF- and conditioned medium from activated hepatic stellate cells. MIA2 is is mainly expressed in hepatocytes. MIA2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain consisting of 101 amino having a total molecular mass of 11.5 kDa. The MIA2 is purified by proprietary chromatographic techniques.
• Amino acid sequence
  MLESTKLLAD LKKCGDLECE ALINRVSAMR DYRGPDCRYL NFTKGEEISV YVKLAGERED LWAGSKGKEF GYFPRDAVQI EEVFISEEIQ MSTKESDFLC L
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  MIA-2  
• Gene symbol
  MIA-RAB4B, MIA2-AS1, MIA, CFAP73, MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2, MIR329-2
• Short name
  MIA-2, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  MIA-2, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:48352
• Gene
  MIA-RAB4B
• Long gene name
  MIA-RAB4B readthrough (NMD candidate)
• Locus
  19q13.2
• Discovery year
  2013-05-10
• Entrez gene record
  100529262
• VEGA ID
  OTTHUMG00000182782

Gene info

• Identity
  HGNC:55436
• Gene
  MIA2-AS1
• Long gene name
  MIA2 antisense RNA 1
• Locus
  14q21.1
• Discovery year
  2021-01-14
• Entrez gene record
  100288846
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:7076
• Gene
  MIA
• Long gene name
  MIA SH3 domain containing
• Synonyms gene name
  • melanoma inhibitory activity
• Synonyms
  • CD-RAP
• GenBank acession
  • X75450
• Locus
  19q13.2
• Discovery year
  1999-12-14
• Entrez gene record
  8190
• Pubmed identfication
  • 7923218
  • 8661134
• Classification
  • MIA family
• VEGA ID
  OTTHUMG00000182693

Gene info

• Identity
  HGNC:37100
• Gene
  CFAP73
• Long gene name
  cilia and flagella associated protein 73
• Synonyms gene
  • CCDC42B
• Synonyms gene name
  • coiled-coil domain containing 42B
• Synonyms
  • MIA2
• Locus
  12q24.13
• Discovery year
  2009-06-19
• Entrez gene record
  387885
• Pubmed identfication
  • 23569216
• RefSeq identity
  • NM_001144872
• Classification
  • Cilia and flagella associated
• VEGA ID
  OTTHUMG00000169655

Gene info

• Identity
  HGNC:35282
• Gene
  MIR1289-2
• Long gene name
  microRNA 1289-2
• Synonyms gene
  • MIRN1289-2
• Synonyms
  • hsa-mir-1289-2
• Locus
  5q31.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302134
• RefSeq identity
  • NR_031621
• Classification
  • MicroRNA MIR1289 family

Gene info

• Identity
  HGNC:32113
• Gene
  MIR521-2
• Long gene name
  microRNA 521-2
• Synonyms gene
  • MIRN521-2
• Synonyms
  • hsa-mir-521-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574481
• RefSeq identity
  • NR_030203
• Classification
  • MicroRNA MIR515 family

Gene info

• Identity
  HGNC:33641
• Gene
  MIR509-2
• Long gene name
  microRNA 509-2
• Synonyms gene
  • MIRN509-2
• Synonyms
  • hsa-mir-509-2
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126301
• RefSeq identity
  • NR_030586
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:32091
• Gene
  MIR512-2
• Long gene name
  microRNA 512-2
• Synonyms gene
  • MIRN512-2
• Synonyms
  • hsa-mir-512-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574459
• RefSeq identity
  • NR_030181
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:31639
• Gene
  MIR7-2
• Long gene name
  microRNA 7-2
• Synonyms gene
  • MIRN7-2
• Synonyms
  • hsa-mir-7-2
• Locus
  15q26.1
• Discovery year
  2004-04-23
• Entrez gene record
  407044
• RefSeq identity
  • NR_029606
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:32051
• Gene
  MIR329-2
• Long gene name
  microRNA 329-2
• Synonyms gene
  • MIRN329-2
• Synonyms
  • hsa-mir-329-2
• Locus
  14q32.31
• Discovery year
  2005-07-11
• Entrez gene record
  574409
• RefSeq identity
  • NR_029968
• Classification
  • MicroRNA MIR329 family

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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