XL-647
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Catalog numberB2204-5
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PricePlease ask
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Size5 mg
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Alternative_nameN-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine; Tesevatinib; EXEL-7647; KD-019
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DescriptionXL-647 is an orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. It binds to and inhibits several receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4).
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CAS Number781613-23-8
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₄H₂₅Cl₂FN₄O₂
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Molecular Weight491.38
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineAn orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID10458325
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SMILESCN1CC2CC(CC2C1)COC3=C(C=C4C(=C3)N=CN=C4NC5=C(C(=C(C=C5)Cl)Cl)F)OC
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InChiInChI=1S/C24H25Cl2FN4O2/c1-31-9-14-5-13(6-15(14)10-31)11-33-21-8-19-16(7-20(21)32-2)24(29-12-28-19)30-18-4-3-17(25)22(26)23(18)27/h3-4,7-8,12-15H,5-6,9-11H2,1-2H3,(H,28,29,30)/t13?,14-,15+
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InChi KeyHVXKQKFEHMGHSL-GOOCMWNKSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolMIR647, BCL2L1, BCL11A
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Short nameXL-647
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Alternative nameXL-647
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Gene info
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Identity
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Gene
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Long gene namemicroRNA 647
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Synonyms gene
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Synonyms
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Locus
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Discovery year2006-05-17
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNAs
Gene info
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Identity
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Gene
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Long gene nameBCL2 like 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-10-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- BCL2 family
- Protein phosphatase 1 regulatory subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameBAF chromatin remodeling complex subunit BCL11A
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Synonyms gene
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Synonyms gene name
- ecotropic viral integration site 9
- B-cell CLL/lymphoma 11A (zinc finger protein)
- B cell CLL/lymphoma 11A
- BCL11A, BAF complex component
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-02-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Zinc fingers C2H2-type
- BAF complex
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VEGA ID
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Locus Specific Databases