LEF1(Ser42) Antibody

• Catalog number
  bs-9842R
• Price
  Please ask
• Size
  0.1ml

• Long name
  LEF1(Ser42) Primary Polyclonal Antibody
• Also known as
  LEF1(Ser42) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  LEF1 Ser42
• Specificity
  This is a highly specific antibody against LEF1 Ser42. This antibody will recognize LEF1(Ser40) in mouse and rat
• Modification s
  Phosphorylation
• Modification site s
  Ser42
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  14-52/399
• Subcellular location
  Nucleus
• Source
  KLH conjugated synthetic phosphopeptide derived from human LEF1 around the phosphorylation site of Ser42
• Gene ID number
  51176
• Swiss Prot
  Q9UJU2
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  LEF-1; TCF10; TCF7L3; TCF1ALPHA; Lymphoid enhancer-binding factor 1; T cell-specific transcription factor 1-alpha; TCF1-alpha; LEF1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  LEF1   Ser42  
• Gene symbol
  LEF1-AS1, LEF1
• Short name
  Anti-LEF1 Ser42
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  LEF1(Ser42) Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  lymphoid enhancer-binding factor 1, LEF1 and IDBG-33529 and ENSG00000138795 and 51176, DNA binding, nuclei, Lef1 and IDBG-194292 and ENSMUSG00000027985 and 16842, LEF1 and IDBG-640560 and ENSBTAG00000006844 and 535399

Gene info

• Identity
  HGNC:40339
• Gene
  LEF1-AS1
• Long gene name
  LEF1 antisense RNA 1
• Synonyms gene name
  • LEF1 antisense RNA 1 (non-protein coding)
• Locus
  4q25
• Discovery year
  2012-05-28
• Entrez gene record
  641518
• Pubmed identfication
  • 27591862
  • 28894380
• RefSeq identity
  • NR_029373
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000161028

Gene info

• Identity
  HGNC:6551
• Gene
  LEF1
• Long gene name
  lymphoid enhancer binding factor 1
• Synonyms gene name
  • lymphoid enhancer-binding factor 1
• Synonyms
  • TCF1ALPHA
  • TCF10
  • TCF7L3
• Locus
  4q25
• Discovery year
  1991-06-05
• Entrez gene record
  51176
• Pubmed identfication
  • 1783375
• Classification
  • TCF/LEF transcription factor family
  • Wnt enhanceosome complex
• VEGA ID
  OTTHUMG00000131809

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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