Target of this antibody:
Alternative names of antibody target:
Tyrosyl-DNA phosphodiesterase 1, TDP1 protein, TDP1.
Tyrosyl-DNA phosphodiesterase (TDP1) is a DNA repair enzyme that catalyzes the hydrolysis of a phophodiester bond between a tyrosine residue and a DNA 3' phosphate. This protein is a member of the phospholipase D (PLD) superfamily and contains two PLD phosphodiesterase domains. Mutations in TDP1 are associated with the disease spino-cerebellar ataxia with axonal neuropathy (SCAN1) by interfering with DNA transcription or by inducting apoptosis in postmitotic neurons.
Clonality of antibody:
This antibody reacts with:
Recombinant human TDP1 (1-298aa) purified from E. Coli. Anti-human TDP1 mAb, clone AT1F2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TDP1 protein.
Concentration of antibody:
Form of antibody:
Formulation of this antibody:
Supplied in PBS with 0.1% sodium azide.
Protein-G affinity purified
This antibody has been succesfully tested for use in following methods:
Western Blot, ELISA
Western blot: ~1:1000 - 2000, ELISA.
Shelf time: 12 months in temp.: -20 deg.C
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
anti-TDP1 Antibody (Clone AT1F2)
antibody to-TDP1 (Antibody to) (clonality AT1F2)