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Alternative name1
Anti-GOAT ANTI HUMAN CD156b (C-TERMINAL)
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Alternative name2
Caprine ANTI HUMAN CD156b (C-TERMINAL)
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Alternative name3
Caprinae ANTI Homo sapiens CD156b (C-TERMINAL)
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Alternative name4
CD156b
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Alternative name5
N/A
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Other names
disintegrin and metalloproteinase domain-containing protein 17 preproprotein; Disintegrin and metalloproteinase domain-containing protein 17; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme; ADAM metallopeptidase domain 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme
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Gene name
CD156b
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Gene name synonims
N/A
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Other gene names
ADAM17; ADAM17; CSVP; TACE; NISBD; ADAM18; CD156B; CSVP; TACE; ADAM 17
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Category
Antibodies
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Clonality
Polyclonal
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Immunoglobulin isotype
Polyclonal IgG
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Clone
Polyclonal antibody
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Host organism
Goat
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Species reactivity
Human
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Specificity and cross reactivity
CD156b This item detects an epitope within the C-terminus of isoform 1 of CD156b, a type I transmembrane glycoprotein which belongs to the ADAM (a disintegrin and metalloprotease domain) family. CD156b is 125kD, and functions as a tumour necrosis factor-alpha converting enzyme (TACE). CD156b also causes a number of inflammatory modulators to undergo ectodomain shedding, including TNFR75, IL-1RII, TNFR55, L-selectin, and the amyloid precursor protein among others. CD156b plays a prominent role in the activation of the Notch signalling pathway. _x000D_ADAM17 plays a pivotal role in several acquired tumor cell capabilities by mediating the availability of soluble transforming growth factor-alpha, and establishing an autocrine signaling pathway through endogenous EGFR activation. CD156b is therefore a prospective therapeutic target in human cancer.
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Purification method
N/A
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Form Appearance
Purified (Purified IgG - liquid)
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Concentration
N/A
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Storage and shipping
Store at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. Storage in frost-free freezers is not recommended. productone should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of dispatch.
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Tested for
Western Blot (WB), ELISA (EIA)
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Description
productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
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Advisory
In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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Properties
If you buy Antibodies supplied by MBS Polyclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Latin name
Capra aegagrus hircus
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French translation
anticorps
