Verapamil hydrochloride

Alternative_name

α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile hydrochloride
Description

Verapamil is a L-type Calcium channel blocker. It has both peripheral and coronary vasodilator effects (IC₅₀ = 0.38 μM in guinea pig aortic strip) and has been used to control hypertension, angina, cardiac arrhythmia, and vascular headaches. Verapamil also acts as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell line.
CAS Number

152-11-4
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₇H₃₈N₂O₄.HCl
Molecular Weight

491.07
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

Water (>40 mg/ml) or DMSO (>20 mg/ml) or EtOH (>20 mg/ml)
Handling

Protect from light and moisture
Tag Line

A L-type calcium channel blocker
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD0005528
PubChem CID

62969
PubChem CID Link
SMILES

CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl
InChi

InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChi Key

DOQPXTMNIUCOSY-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes