CEP-32496

Alternative_name

1-(3-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea; AC013773
Description

CEP-32496 specific and selective inhibitor of the activity of the mutated form (V600E) of B-raf kinase. It inhibits the activation of the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway and may result in a decrease in the proliferation of tumor cells expressing the mutated B-raf gene.
CAS Number

1188910-76-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₄H₂₂F₃N₅O₅
Molecular Weight

517.47
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A specific and selective inhibitor of the activity of the mutated form (V600E) of B-raf kinase.
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

56846693
PubChem CID Link
SMILES

CC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F
InChi

InChI=1S/C24H22F3N5O5/c1-23(2,24(25,26)27)19-11-20(32-37-19)31-22(33)30-13-6-5-7-14(8-13)36-21-15-9-17(34-3)18(35-4)10-16(15)28-12-29-21/h5-12H,1-4H3,(H2,30,31,32,33)
InChi Key

DKNUPRMJNUQNHR-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes