EZSolution™ TGR5 Receptor Agonist
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Catalog number2538-5
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Price:
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Size5 mg
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Alternative_name3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide
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DescriptionCell-permeable, small molecule agonist of TGR5 G-protein coupled receptor. This agonist has shown to increase glucagon like peptide-1 (GLP-1) secretion from primary intestinal cells.
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₈H₁₄Cl₂N₂O₂
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Molecular Weight361.22
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Cell PermeableYes
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Purity≥98% by HPLC
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HandlingProtect from air and moisture
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Tag LineA TGR5 agonist
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life12 months
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SMILESN/A
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InChiN/A
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InChi KeyN/A
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MSDS AvailableYes
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Additional descriptionThe receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbolGPBAR1
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Short nameEZSolution™ TGR5 Receptor Agonist
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Alternative nameEZSolution™ TGR5 Receptor Agonist
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Gene info
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Identity
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Gene
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Long gene nameG protein-coupled bile acid receptor 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-01-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- G protein-coupled bile acid receptor
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VEGA ID