NU-7441

• Catalog number
  B1117-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one; KU-57788
• Description
  NU-7441 is a potent and selective DNA-PK inhibitor (IC₅₀ = 14 nM). Displays selectivity for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency, and attenuates nonhomologous end-joining (NHEJ).
• CAS Number
  503468-95-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₅H₁₉NO₃S
• Molecular Weight
  413.49
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 2 mg/ml with gentle warming)
• Handling
  Protect from air and light
• Tag Line
  A potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and HDR enhancer
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD11983069
• PubChem CID
  11327430
• PubChem CID Link
• SMILES
  C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56
• InChi
  InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
• InChi Key
  JAMULYFATHSZJM-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  NU-7441  
• Gene symbol
  PSMA1
• Short name
  NU-7441
• Alternative name
  NU-7441

Gene info

• Identity
  HGNC:9530
• Gene
  PSMA1
• Long gene name
  proteasome 20S subunit alpha 1
• Synonyms gene name
  • proteasome (prosome, macropain) subunit, alpha type, 1
  • proteasome subunit alpha 1
• Synonyms
  • HC2
  • NU
  • PROS30
  • MGC14542
  • MGC14575
  • MGC14751
  • MGC1667
  • MGC21459
  • MGC22853
  • MGC23915
• Synonyms name
  • proteasome subunit α6
• GenBank acession
  • X61969
• Locus
  11p15.2
• Discovery year
  1995-05-03
• Entrez gene record
  5682
• Pubmed identfication
  • 1398136
  • 2025653
• RefSeq identity
  • NM_002786
• Classification
  • Proteasome
• VEGA ID
  OTTHUMG00000165825

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