Ezatiostat

Alternative_name

(S)-Ethyl 2-amino-5-(((R)-3-(benzylthio)-1-(((S)-2-ethoxy-2-oxo-1-phenylethyl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoate; TLK199; TLK-199; TLK 199
Description

Ezatiostat is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity. After intracellular de-esterification, the active form of ezatiostat binds to and inhibits GST P1-1, thereby restoring Jun kinase and MAPK pathway activities and promoting MAPK-mediated cellular proliferation and differentiation pathways. Ezatiostat promotes the proliferation and maturation of hematopoietic precursor cells, granulocytes, monocytes, erythrocytes and platelets.
CAS Number

168682-53-9
Structure Available

Y
Salt Form

No
Molecular Formula

C₂₇H₃₅N₃O₆S
Molecular Weight

529.65
Cell Permeable

Yes
Purity

>98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A glutathione S-transferase (GST) P1-1 inhibitor
Storage Condition

-20 ̊C
Shipping Condition

Gel pack
Shelf Life

36 months
PubChem CID

5310939
PubChem CID Link
SMILES

CCOC(=O)C(CCC(=O)NC(CSCC1=CC=CC=C1)C(=O)NC(C2=CC=CC=C2)C(=O)OCC)N
InChi

InChI=1S/C27H35N3O6S/c1-3-35-26(33)21(28)15-16-23(31)29-22(18-37-17-19-11-7-5-8-12-19)25(32)30-24(27(34)36-4-2)20-13-9-6-10-14-20/h5-14,21-22,24H,3-4,15-18,28H2,1-2H3,(H,29,31)(H,30,32)/t21-,22-,24+/m0/s1
InChi Key

GWEJFLVSOGNLSS-WPFOTENUSA-N
Data Sheet Link
MSDS Available

Yes