GSK-106 hydrochloride
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Catalog numberB1036-500
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PricePlease ask
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Size500 ug
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Alternative_name(3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzo[d]imidazol-6-yl)methanone hydrochloride
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DescriptionGSK-106 is a useful negative control for PAD4 inhibitors (GSK-121 and GSK-484). It does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils (IC₅₀s > 100 µM).
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CAS Number1652591-82-6
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₄H₂₈ClN₅O
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Molecular Weight437.97
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Cell PermeableYes
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Purity≥98%
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SolubilitiesDMSO (~30 mg/ml)
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HandlingProtect from air and moisture
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Tag LineA useful negative control for PAD4 inhibitors GSK-121 and GSK-484.
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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SMILESO=C(N1CC(N)CCC1)C2=CC=C3C(N(C)C(C(N4CC)=CC5=C4C=CC=C5)=N3)=C2.[H]Cl
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InChiInChI=1S/C24H27N5O.ClH/c1-3-29-20-9-5-4-7-16(20)13-22(29)23-26-19-11-10-17(14-21(19)27(23)2)24(30)28-12-6-8-18(25)15-28;/h4-5,7,9-11,13-14,18H,3,6,8,12,15,25H2,1-2H3;1H
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InChi KeyVRPFLFUQMWOJAT-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolPRELID1, OR8C1P
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Short nameGSK-106 hydrochloride
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Alternative nameGSK-106 hydrochloride
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Gene info
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Identity
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Gene
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Long gene namePRELI domain containing 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2007-02-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- PRELI domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameolfactory receptor family 8 subfamily C member 1 pseudogene
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Synonyms gene
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Synonyms gene name
- olfactory receptor, family 8, subfamily C, member 1 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-11-09
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Entrez gene record
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Pubmed identfication
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Classification
- Olfactory receptors, family 8
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VEGA ID