NVP-BHG712

• Catalog number
  2464-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  4-Methyl-3-[[1-methyl-6-(3-pyridiny l)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(t rifluoromethyl)phenyl]benzamide
• Description
  A potent, selective small-molecule inhibitor of the receptor tyrosine kinase EphB4 (ED₅₀ = 25 nM). Displays selectivity for EphB4 over >40 other kinases in vitro, including FGFR3. NVP-BHG712 blocks Ephrin receptor autophosphorylation and VEGF-induced angiogenesis.
• CAS Number
  940310-85-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₆H₂₀F₃N₇O
• Molecular Weight
  503.48
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (> 100 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent, inhibitor of the receptor tyrosine kinase EphB4
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• PubChem CID
  16747388
• PubChem CID Link
• SMILES
  CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=Canonical SMILES : CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5
• InChi
  InChI=1S/C26H20F3N7O/c1-15-8-9-16(25(37)32-19-7-3-6-18(12-19)26(27,28)29)11-21(15)33-23-20-14-31-36(2)24(20)35-22(34-23)17-5-4-10-30-13-17/h3-14H,1-2H3,(H,32,37)(H,33,34,35)
• InChi Key
  ZCCPLJOKGAACRT-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  NVP-BHG712  
• Short name
  NVP-BHG712
• Alternative name
  NVP-BHG712

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