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Alternative_name
p-Methoxyphenyl)morpholino-phosphinodithioic acid
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Description
A slow-releasing, water-soluble hydrogen sulfide (H₂S) donor. Displays vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Inhibits LPS-induced release of various proinflammatory mediators (such as IL-1β, IL-6, TNF-α, nitric oxide (NO) and PGE2) in RAW264.7 cells. Increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-κB, ATF-2 and HSP27 dependent pathways in RAW264.7 cells.
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CAS Number
106740-09-4
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₁H₁₅NO₂PS₂ · C₄H₁₀NO
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Molecular Weight
376.47
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Cell Permeable
Yes
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Purity
≥95% by HPLC
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Solubilities
DMSO (15 mg/ml) or water (30 mg/ml)
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Handling
Protect from air and moisture
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Tag Line
A slow-releasing, water-soluble hydrogen sulfide (H₂S) donor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD00079328
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PubChem CID
53393943
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SMILES
COC1=CC=C(C=C1)P(=S)(N2CCOCC2)[S-].C1COCC[NH2+]1
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InChi
InChI=1S/C11H16NO2PS2.C4H9NO/c1-13-10-2-4-11(5-3-10)15(16, 17)12-6-8-14-9-7-12;1-3-6-4-2-5-1/h2-5H,6-9H2,1H3,(H,16,17);5H,1-4H2
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InChi Key
YZMHNNLDUWRZFW-UHFFFAOYSA-N
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MSDS Available
Yes
