HBX-41108

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• Catalog number
  9608-25
• Price:

  899.98 USD

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• Size
  25 mg

# #

• Alternative_name
  7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
• Description
  HBX-41108 is a potent inhibitor of ubiquitin-specific protease (USP) 7 activity (IC₅₀ = 424 nM). Also inhibits USP7-mediated p53 deubiquitination (IC₅₀ = 0.8 μM). HBX-41108 treatment stabilizes p53, activates the transcription of a p53 target gene without inducing genotoxic stress, and inhibits cancer cell growth. Also induces p53-dependent apoptosis in p53 wild type and isogenic cancer cell lines.
• CAS Number
  924296-39-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₃H₃ClN₄O
• Molecular Weight
  266.64
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>20 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent inhibitor of ubiquitin-specific protease (USP) 7 activity
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  16065773
• PubChem CID Link
• SMILES
  C1=CC2=C(C=C1Cl)C(=O)C3=NC(=C(N=C23)C#N)C#N
• InChi
  InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
• InChi Key
  BIGPXXAUSQLTQR-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

#

• Gene target
  HBX-41108  
• Short name
  HBX-41108
• Alternative name
  HBX-41108

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