LY-2090314

Alternative_name

3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione
Description

LY-2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) (IC₅₀ = 1.5 NM for GSK-3α and 0.9 nM for GSK-3β). LY-2090314 plays an important role in many pathways, including initiation of protein synthesis, cell proliferation, cell differentiation, and apoptosis.
CAS Number

603288-22-8
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₈H₂₅FN₆O₃
Molecular Weight

512.53
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~10 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3)
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

10029385
PubChem CID Link
SMILES

C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7
InChi

InChI=1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16H,1,3-4,7-8,10-11,15H2,(H,31,36,37)
InChi Key

HRJWTAWVFDCTGO-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes