ML-162

Alternative_name

α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide
Description

ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).
CAS Number

1035072-16-2
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₃H₂₂Cl₂N₂O₃S
Molecular Weight

477.4
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>20 mg/ml)
Handling

Protect from air and light
Tag Line

A GPX4 (glutathione peroxidase 4) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

3689413
PubChem CID Link
SMILES

COC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl
InChi

InChI=1S/C23H22Cl2N2O3S/c1-30-19-10-9-17(14-18(19)25)27(21(28)15-24)22(20-8-5-13-31-20)23(29)26-12-11-16-6-3-2-4-7-16/h2-10,13-14,22H,11-12,15H2,1H3,(H,26,29)
InChi Key

UNVKYJSNMVDZJE-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

YES

Identity

HGNC:21549
Gene

FAM162B
Long gene name

family with sequence similarity 162 member B
Synonyms gene
- C6orf189
Synonyms gene name
- chromosome 6 open reading frame 189
- family with sequence similarity 162, member B
Synonyms
- bA86F4.2
GenBank acession
- BC038997
Locus

6q22.1
Discovery year

2003-06-24
Entrez gene record

221303
RefSeq identity
- NM_001085480
VEGA ID

OTTHUMG00000015446