Cell-permeable. A bioactive flavonoid antioxidant found in the flowering hops plant. Binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II). Impairs prostate cancer cell growth and proliferation.
Is it cell-permeable?
≥98% by TLC
Is this a salt?
Protect from light and mositure
Maximum time for storage
DMSO (~35 mg/ml) or EtOH (~35 mg/ml)
For cells, cell lines and tissues in culture till half confluency.