Fbxw7 Antibody, ALEXA FLUOR 647

• Catalog number
  bs-8394R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  Fbxw7 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-Fbxw7 PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Fbxw7
• Specificity
  This is a highly specific antibody against Fbxw7.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  519-549/707
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Fbxw7/hCDC4
• Gene ID Number
  55294
• Swiss Prot
  Q969H0
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463).
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  AGO; CDC4; FBW6; FBW7; hAgo; FBX30; FBXW6; SEL10; hCdc4; FBXO30; SEL-10; F-box/WD repeat-containing protein 7; Archipelago homolog; F-box and WD-40 domain-containing protein 7; F-box protein FBX30; FBXW7
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-Fbxw7 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  Fbxw7  
• Gene symbol
  FBXW7-AS1, FBXW7
• Short name
  Anti-Fbxw7
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  Fbxw7 Polyclonal Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:52397
• Gene
  FBXW7-AS1
• Long gene name
  FBXW7 antisense RNA 1
• Synonyms
  • DEAR
  • DEspR
• Synonyms name
  • dual-endothelin1/VEGFsp receptor
  • dual endothelin-1(VEGFsp)/angiotensin II receptor
• Locus
  4q31.3
• Discovery year
  2016-10-13
• Entrez gene record
  102191832
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000185247

Gene info

• Identity
  HGNC:16712
• Gene
  FBXW7
• Long gene name
  F-box and WD repeat domain containing 7
• Synonyms gene name
  • F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
• Synonyms
  • AGO
  • FLJ11071
  • SEL-10
  • SEL10
  • FBW7
  • FBX30
  • CDC4
  • FBXW6
• Synonyms name
  • archipelago homolog (Drosophila)
• GenBank acession
  • AF411971
• Locus
  4q31.3
• Discovery year
  2001-12-20
• Entrez gene record
  55294
• Pubmed identfication
  • 10531037
  • 11425854
• Classification
  • WD repeat domain containing
  • MicroRNA protein coding host genes
  • F-box and WD repeat domain containing
• VEGA ID
  OTTHUMG00000185246
• Locus Specific Databases
  • LRG_1141

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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