Fbxw7 Antibody, ALEXA FLUOR 350

• Catalog number
  bs-8394R-A350
• Price
  Please ask
• Size
  100ul

• Long name
  Fbxw7 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
• Also known as
  Anti-Fbxw7 PAb ALEXA FLUOR 350
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 350
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Fbxw7
• Specificity
  This is a highly specific antibody against Fbxw7.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  519-549/707
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Fbxw7/hCDC4
• Gene ID Number
  55294
• Swiss Prot
  Q969H0
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463).
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  343nm/442nm
• Synonyms
  AGO; CDC4; FBW6; FBW7; hAgo; FBX30; FBXW6; SEL10; hCdc4; FBXO30; SEL-10; F-box/WD repeat-containing protein 7; Archipelago homolog; F-box and WD-40 domain-containing protein 7; F-box protein FBX30; FBXW7
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 350
• French translation
  anticorps

• Gene target
  Fbxw7  
• Gene symbol
  FBXW7-AS1, FBXW7
• Short name
  Anti-Fbxw7
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 350
• Alternative name
  Fbxw7 Polyclonal Antibody, ALEXA FLUOR 350
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:52397
• Gene
  FBXW7-AS1
• Long gene name
  FBXW7 antisense RNA 1
• Synonyms
  • DEAR
  • DEspR
• Synonyms name
  • dual-endothelin1/VEGFsp receptor
  • dual endothelin-1(VEGFsp)/angiotensin II receptor
• Locus
  4q31.3
• Discovery year
  2016-10-13
• Entrez gene record
  102191832
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000185247

Gene info

• Identity
  HGNC:16712
• Gene
  FBXW7
• Long gene name
  F-box and WD repeat domain containing 7
• Synonyms gene name
  • F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
• Synonyms
  • AGO
  • FLJ11071
  • SEL-10
  • SEL10
  • FBW7
  • FBX30
  • CDC4
  • FBXW6
• Synonyms name
  • archipelago homolog (Drosophila)
• GenBank acession
  • AF411971
• Locus
  4q31.3
• Discovery year
  2001-12-20
• Entrez gene record
  55294
• Pubmed identfication
  • 10531037
  • 11425854
• Classification
  • WD repeat domain containing
  • MicroRNA protein coding host genes
  • F-box and WD repeat domain containing
• VEGA ID
  OTTHUMG00000185246
• Locus Specific Databases
  • LRG_1141

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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