I-BET726

• Catalog number
  B1569-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]-benzoic acid; GSK1324726A
• Description
  I-BET276 is a potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC₅₀ = 41 nM), BRD3 (IC₅₀ = 31 nM), and BRD4 (IC₅₀ = 22 nM).
• CAS Number
  1300031-52-0
• Structure Available
  Yes
• Molecular Formula
  C₂₅H₂₃ClN₂O₃
• Molecular Weight
  435
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent, and selective small molecule inhibitor of BET proteins
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  52912222
• PubChem CID Link
• SMILES
  CC1CC(C2=C(N1C(=O)C)C=CC(=C2)C3=CC=C(C=C3)C(=O)O)NC4=CC=C(C=C4)Cl
• InChi
  InChI=1S/C25H23ClN2O3/c1-15-13-23(27-21-10-8-20(26)9-11-21)22-14-19(7-12-24(22)28(15)16(2)29)17-3-5-18(6-4-17)25(30)31/h3-12,14-15,23,27H,13H2,1-2H3,(H,30,31)/t15-,23+/m0/s1
• InChi Key
  FAWSUKOIROHXAP-NPMXOYFQSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  I-BET726  
• Gene symbol
  FABP6, TANK, FABP2, PSMB2, CPLX1, MDFI, B3GAT3, IGLVI-38, XYLT1
• Short name
  I-BET726
• Alternative name
  I-BET726

Gene info

• Identity
  HGNC:3561
• Gene
  FABP6
• Long gene name
  fatty acid binding protein 6
• Synonyms gene name
  • fatty acid binding protein 6, ileal
• Synonyms
  • I-15P
  • ILLBP
  • I-BAP
  • ILBP3
  • I-BABP
  • ILBP
  • I-BALB
• Synonyms name
  • illeal lipid-binding protein
  • ileal bile acid binding protein
  • gastrotropin
• GenBank acession
  • U19869
• Locus
  5q33.3
• Discovery year
  1997-09-12
• Entrez gene record
  2172
• Pubmed identfication
  • 7894165
  • 7619861
• RefSeq identity
  • NM_001040442
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000130329

Gene info

• Identity
  HGNC:11562
• Gene
  TANK
• Long gene name
  TRAF family member associated NFKB activator
• Synonyms gene
  • TRAF2
• Synonyms gene name
  • TRAF family member-associated NFKB activator
• Synonyms
  • I-TRAF
• GenBank acession
  • U59863
• Locus
  2q24.2
• Discovery year
  1997-06-12
• Entrez gene record
  10010
• Pubmed identfication
  • 8710854
  • 8855313
• RefSeq identity
  • NM_133484
• VEGA ID
  OTTHUMG00000132037

Gene info

• Identity
  HGNC:3556
• Gene
  FABP2
• Long gene name
  fatty acid binding protein 2
• Synonyms gene name
  • fatty acid binding protein 2, intestinal
• Synonyms
  • I-FABP
• GenBank acession
  • J03465
• Locus
  4q26
• Discovery year
  1986-01-01
• Entrez gene record
  2169
• RefSeq identity
  • NM_000134
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000132972

Gene info

• Identity
  HGNC:9539
• Gene
  PSMB2
• Long gene name
  proteasome 20S subunit beta 2
• Synonyms gene name
  • proteasome (prosome, macropain) subunit, beta type, 2
  • proteasome subunit beta 2
• Synonyms
  • HC7-I
• Synonyms name
  • proteasome subunit β4
• GenBank acession
  • D26599
• Locus
  1p34.3
• Discovery year
  1995-05-03
• Entrez gene record
  5690
• Pubmed identfication
  • 7918633
• RefSeq identity
  • NM_002794
• Classification
  • Proteasome
• VEGA ID
  OTTHUMG00000004169

Gene info

• Identity
  HGNC:2309
• Gene
  CPLX1
• Long gene name
  complexin 1
• Synonyms
  • CPX-I
• GenBank acession
  • AF022383
• Locus
  4p16.3
• Discovery year
  1999-09-09
• Entrez gene record
  10815
• Pubmed identfication
  • 7553862
• VEGA ID
  OTTHUMG00000160005

Gene info

• Identity
  HGNC:6967
• Gene
  MDFI
• Long gene name
  MyoD family inhibitor
• Synonyms
  • I-mfa
• Synonyms name
  • inhibitor of MyoD family a
• GenBank acession
  • U78313
• Locus
  6p21.1
• Discovery year
  1997-10-17
• Entrez gene record
  4188
• Pubmed identfication
  • 9250874
  • 17289077
• RefSeq identity
  • NM_005586
• VEGA ID
  OTTHUMG00000014681

Gene info

• Identity
  HGNC:923
• Gene
  B3GAT3
• Long gene name
  beta-1,3-glucuronyltransferase 3
• Synonyms gene name
  • beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
• Synonyms
  • GlcAT-I
• Synonyms name
  • glucuronosyltransferase I
  • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
• GenBank acession
  • AB009598
• Locus
  11q12.3
• Discovery year
  2000-01-07
• Entrez gene record
  26229
• Pubmed identfication
  • 9506957
• RefSeq identity
  • NM_012200
• Classification
  • Beta-1,3-glucuronyltransferases
• VEGA ID
  OTTHUMG00000167685

Gene info

• Identity
  HGNC:5935
• Gene
  IGLVI-38
• Long gene name
  immunoglobulin lambda variable (I)-38 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable (I)-38
  • immunoglobulin lambda variable (I)-38 pseudogene
• Synonyms
  • IGLV(I)-38
• GenBank acession
  • D87009
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28768
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151073

Gene info

• Identity
  HGNC:15516
• Gene
  XYLT1
• Long gene name
  xylosyltransferase 1
• Synonyms gene name
  • xylosyltransferase I
• Synonyms
  • XT-I
  • PXYLT1
• Synonyms name
  • protein xylosyltransferase 1
• GenBank acession
  • AJ277441
• Locus
  16p12.3
• Discovery year
  2001-04-06
• Entrez gene record
  64131
• Pubmed identfication
  • 11099377
  • 23982343
• RefSeq identity
  • NM_022166
• Classification
  • Glucosaminyl (N-acetyl) transferases/xylosyltransferases
• VEGA ID
  OTTHUMG00000129975

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