MHC class I Antibody, ALEXA FLUOR 350

• Catalog number
  bs-10251R-A350
• Price
  Please ask
• Size
  100ul

• Long name
  MHC class I Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
• Also known as
  Anti-MHC class I PAb ALEXA FLUOR 350
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 350
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  MHC class I
• Specificity
  This is a highly specific antibody against MHC class I.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  60-105/181
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MHC class I
• Swiss Prot
  G0ZMJ8
• Tested applications
  FCM, IF(IHC-P)
• Recommended dilutions
  FCM(1:20-100), IF(IHC-P)(1:50-200)
• Crossreactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  343nm/442nm
• Synonyms
  A 28; A 9; Aw 24; Aw 68; CLASS I HISTOCOMPATIBILITY ANTIGEN; H2 K1; H2K; HLA A; HLA-A; HLA C; HLA-C; HLA class I histocompatibility antigen A 1 alpha chain; HLA class I histocompatibility antigen A 11 alpha chain; HLA class I histocompatibility antigen A 2 alpha chain; HLA class I histocompatibility antigen A 24 alpha chain; HLA class I histocompatibility antigen A 3 alpha chain; HLA class I histocompatibility antigen A 30 alpha chain; HLA class I histocompatibility antigen A 32 alpha chain; HLA class I histocompatibility antigen A 68 alpha chain; HLAA; Major histocompatibility complex class I A; MHC class I heavy chain H2 K; 1C04_HUMAN.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 350
• French translation
  anticorps

• Gene target
  MHC   class  
• Gene symbol
  MICD, MICF, MICG
• Short name
  Anti-MHC class I
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 350
• Alternative name
  MHC class I Polyclonal Antibody, ALEXA FLUOR 350
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7093
• Gene
  MICD
• Long gene name
  MHC class I polypeptide-related sequence D (pseudogene)
• Synonyms gene name
  • MHC class I polypeptide-related sequence D
  • MHC class I polypeptide-related sequence D, pseudogene
• Synonyms
  • PERB11.4
• Locus
  6p22.1
• Discovery year
  1994-09-07
• Entrez gene record
  4279
• Pubmed identfication
  • 8022771
  • 10557312
• RefSeq identity
  • NG_015983
• VEGA ID
  OTTHUMG00000031082

Gene info

• Identity
  HGNC:16801
• Gene
  MICF
• Long gene name
  MHC class I polypeptide-related sequence F (pseudogene)
• Synonyms gene name
  • MHC class I polypeptide-related sequence F, pseudogene
• Locus
  6p22.1
• Discovery year
  2003-05-22
• Entrez gene record
  352957
• Pubmed identfication
  • 10557312
• VEGA ID
  OTTHUMG00000031085

Gene info

• Identity
  HGNC:16802
• Gene
  MICG
• Long gene name
  MHC class I polypeptide-related sequence G (pseudogene)
• Synonyms gene name
  • MHC class I polypeptide-related sequence G, pseudogene
• Locus
  6p22.1
• Discovery year
  2003-05-22
• Entrez gene record
  352967
• Pubmed identfication
  • 10557312
• VEGA ID
  OTTHUMG00000031087

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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