SKPin C1

• Catalog number
  2343-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  2-[4-Bromo-2-[[4-oxo-3-(3-pyridinyl­methyl)-2-thioxo-5-thiazolidinylidene]methyl]pheno­xy]acetic acid
• Description
  Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases.
• CAS Number
  432001-69-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₁₃BrN₂O₄S₂
• Molecular Weight
  465.34
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (15 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  An ubiquitin E3 ligase inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• SMILES
  BrC1=CC(/C=C2SC(N(CC3=CN=CC=C3)C\2=O)=S)=C(OCC(O)=O)C=C1
• InChi
  InChI=1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7-
• InChi Key
  IYCJJVVXEHZJHE-CHHVJCJISA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SKPin  
• Short name
  SKPin C1
• Alternative name
  SKPin C1

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