TEPP-46

• Catalog number
  B2164-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  6-[(3-aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)-5H-thieno[2’,3’:4,5]pyrrolo[2,3-d]pyridazin-5-one; CID-44246499,NCGC00186528, ML-265
• Description
  TEPP-46 (ML-265) is a potent and selective PKM2 activator. TEPP-46 activates tumor-specific PKM2 (EC₅₀ = 92 nM) by binding to the dimer-dimer interface between two subunits of PKM2 and inducing tetramerization, which is the most active form of the enzyme. In mice with A549 xenograft tumors, ML-265 displays good oral bioavailability with relatively low clearance, long half-life.
• CAS Number
  1221186-53-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₇H₁₆N4O₂S₂
• Molecular Weight
  372.5
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent and selective PKM2 activator
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  44246499
• PubChem CID Link
• SMILES
  CN1C2=C(C3=C1C(=O)N(N=C3)CC4=CC(=CC=C4)N)SC(=C2)S(=O)C
• InChi
  InChI=1S/C17H16N4O2S2/c1-20-13-7-14(25(2)23)24-16(13)12-8-19-21(17(22)15(12)20)9-10-4-3-5-11(18)6-10/h3-8H,9,18H2,1-2H3
• InChi Key
  ZWKJWVSEDISQIS-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  TEPP-46  
• Gene symbol
  TEPP, IGLV7-46, IGHV1-46, IGHVII-46-1, SNORD115-46, RNU6-46P, LAMP5, OR7E110P
• Short name
  TEPP-46
• Alternative name
  TEPP-46

Gene info

• Identity
  HGNC:33745
• Gene
  TEPP
• Long gene name
  testis, prostate and placenta expressed
• GenBank acession
  • BC104458
• Locus
  16q21
• Discovery year
  2009-04-20
• Entrez gene record
  374739
• Pubmed identfication
  • 14652002
  • 19548082
• RefSeq identity
  • NM_199456
• VEGA ID
  OTTHUMG00000133463

Gene info

• Identity
  HGNC:5930
• Gene
  IGLV7-46
• Long gene name
  immunoglobulin lambda variable 7-46
• Synonyms gene name
  • immunoglobulin lambda variable 7-46 (gene/pseudogene)
• GenBank acession
  • Z73674
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28775
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151040

Gene info

• Identity
  HGNC:5554
• Gene
  IGHV1-46
• Long gene name
  immunoglobulin heavy variable 1-46
• GenBank acession
  • X92343
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28465
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000151963

Gene info

• Identity
  HGNC:5682
• Gene
  IGHVII-46-1
• Long gene name
  immunoglobulin heavy variable (II)-46-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-46-1
  • immunoglobulin heavy variable (II)-46-1 pseudogene
• Synonyms
  • IGHV(II)-46-1
• GenBank acession
  • AB019438
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28365
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000151952

Gene info

• Identity
  HGNC:42798
• Gene
  SNORD115-46
• Long gene name
  small nucleolar RNA, C/D box 115-46
• Synonyms
  • HBII-52-46
• Locus
  15q11.2 not on reference assembly
• Discovery year
  2011-08-22
• Entrez gene record
  100873857
• RefSeq identity
  • NR_047033
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:34290
• Gene
  RNU6-46P
• Long gene name
  RNA, U6 small nuclear 46, pseudogene
• Synonyms gene
  • RNU6-46
• Synonyms gene name
  • RNA, U6 small nuclear 46
• Locus
  11q13.2
• Discovery year
  2008-06-10
• Entrez gene record
  100873760
• RefSeq identity
  • NR_046497

Gene info

• Identity
  HGNC:16097
• Gene
  LAMP5
• Long gene name
  lysosomal associated membrane protein family member 5
• Synonyms gene
  • C20orf103
• Synonyms gene name
  • chromosome 20 open reading frame 103
  • lysosomal-associated membrane protein family, member 5
• Synonyms
  • dJ1119D9.3
  • BAD-LAMP
  • UNC-46
• Synonyms name
  • brain and dendritic cell associated LAMP
• GenBank acession
  • AL121740
• Locus
  20p12.2
• Discovery year
  2001-07-17
• Entrez gene record
  24141
• Pubmed identfication
  • 11780052
  • 21642595
• RefSeq identity
  • NM_012261
• Classification
  • Lysosome associated membrane proteins
• VEGA ID
  OTTHUMG00000031851

Gene info

• Identity
  HGNC:15126
• Gene
  OR7E110P
• Long gene name
  olfactory receptor family 7 subfamily E member 110 pseudogene
• Synonyms gene
  • OR7E68P
  • OR7E71P
  • OR7E72P
  • OR7E73P
  • OR7E74P
  • OR7E75P
• Synonyms gene name
  • olfactory receptor, family 7, subfamily E, member 110 pseudogene
• Synonyms
  • hg674
  • OR912-109
  • OR912-46
  • OR912-108
  • OR912-110
  • hg523
• Locus
  10p13
• Discovery year
  2001-03-28
• Entrez gene record
  81354
• Classification
  • Olfactory receptors, family 7
• VEGA ID
  OTTHUMG00000017715

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