OPA1 shRNA Plasmid (Rat)

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Kit

Plasmid mini made and maxi DNA purification kits can be silica gel or anion exchange, endotoxin free and are used to produce pure plasmids that are small DNA molecules within a cell separated from chromosomal DNA and can replicate independently. They are most commonly found in bacteria as small circular, double-stranded DNA molecules; however, plasmids are sometimes present in archaea and eukaryotic organisms. In nature, plasmids often carry genes that may benefit the survival of the organism, for example antibiotic resistance. While the chromosomes are big and contain all the essential information for living, plasmids usually are very small and contain only additional information. Artificial plasmids are widely used as vectors in molecular cloning, serving to drive the replication of recombinant DNA sequences within host organisms.
About

Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
Latin name

Rattus norvegicus

Gene target

OPA1 shRNA
Gene symbol

OPA1-AS1, OPA1, MED12
Short name

OPA1 shRNA Plasmid ( )
Technique

plasmid, plasmids in 1
Host

Rat
Species

Rat, Rats
Alternative name

optic atrophy 1 (autosomal dominant) short hairpin RNA Plasmid (Rat)
Alternative technique

plasmids
Alternative to gene target

optic atrophy 1 (autosomal dominant), largeG and MGM1 and NPG and NTG, OPA1 and IDBG-70072 and ENSG00000198836 and 4976, GTP binding, Plasma membranes, Opa1 and IDBG-151468 and ENSMUSG00000038084 and 74143, OPA1 and IDBG-634327 and ENSBTAG00000019514 and 524142

Identity

HGNC:8140
Gene

OPA1
Long gene name

OPA1 mitochondrial dynamin like GTPase
Synonyms gene name
- optic atrophy 1 (autosomal dominant)
- OPA1, mitochondrial dynamin like GTPase
Synonyms
- NTG
- KIAA0567
- FLJ12460
- NPG
- MGM1
Synonyms name
GenBank acession
- AB011139
Locus

3q29
Discovery year

1987-09-11
Entrez gene record

4976
Pubmed identfication
- 9490303
RefSeq identity
- NM_130837
VEGA ID

OTTHUMG00000149897
Locus Specific Databases
- Mutations of the Optic Atrophy 1 Gene
- LRG_337

Identity

HGNC:11957
Gene

MED12
Long gene name

mediator complex subunit 12
Synonyms gene
- TNRC11
- FGS1
Synonyms gene name
- trinucleotide repeat containing 11 (THR-associated protein, 230kDa subunit)
- mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae)
- FG syndrome 1
Synonyms
- CAGH45
- HOPA
- OPA1
- TRAP230
- KIAA0192
- OKS
- ARC240
- Kto
Synonyms name
- Kohtalo homolog
GenBank acession
- U80742
Locus

Xq13.1
Discovery year

2000-01-27
Entrez gene record

9968
Pubmed identfication
- 9225980
- 10198638
- 17334363
- 20507344
RefSeq identity
- NM_005120
Classification
- Mediator complex
VEGA ID

OTTHUMG00000021788
Locus Specific Databases
- Global Variome shared LOVD