Etoposide

Alternative_name

4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside, VP-16-213
Description

A topoisomerase II inhibitor. A derivative of podophyllotoxin that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in human T cells, mouse thymocytes, and HL-60 human leukemia cells
CAS Number

33419-42-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₂H₂₉FO₅
Molecular Weight

588.56
Cell Permeable

Yes
Purity

>98% by HPLC
Solubilities

DMSO ( 25 mg/ml)
Handling

Protect from light and moisture
Tag Line

A topoisomerase II inhibitor
Storage Condition

-20°C
Shipping Condition

RT
Shelf Life

12 months
MDL Number

MFCD00869325
PubChem CID

36462
PubChem CID Link
SMILES

CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
InChi

InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
InChi Key

VJJPUSNTGOMMGY-MRVIYFEKSA-N
Data Sheet Link
MSDS Available

Yes