GSK429286A

Alternative_name

4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide; GSK429286
Description

GSK429286A is a potent and selective Rho-Kinase (ROCK) inhibitor (IC₅₀ = 14 and 63 nM for ROCK1 and ROCK2, respectively). ROCK inhibitors have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency.
CAS Number

864082-47-3
Structure Available

Y
Salt Form

No
Molecular Formula

C₂₁H₁₆F₄N₄O₂
Molecular Weight

432.27
Cell Permeable

Yes
Purity

>98% by HPLC
Solubilities

DMSO (~40 mg/ml) or EtOH (~10 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective Rho-kinase (ROCK) inhibitor
Storage Condition

-20 ̊C
Shipping Condition

Gel pack
Shelf Life

36 months
MDL Number

MFCD16618404
PubChem CID

11373846
PubChem CID Link
SMILES

CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F
InChi

nChI=1S/C21H16F4N4O2/c1-10-19(20(31)28-17-6-12-9-26-29-16(12)8-15(17)22)14(7-18(30)27-10)11-2-4-13(5-3-11)21(23,24)25/h2-6,8-9,14H,7H2,1H3,(H,26,29)(H,27,30)(H,28,31)
InChi Key

OLIIUAHHAZEXEX-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes