GANT58

• Catalog number
  1812-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503
• Description
  Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC₅₀ ~ 5 µM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.
• CAS Number
  64048-12-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₄H₁₆N₄S
• Molecular Weight
  392.48
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (25 mM) or Ethanol (25 mM)
• Handling
  Protect from air and light
• Tag Line
  A Hedgehog (Hh) signaling pathway inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD01103196
• PubChem CID
  253078
• PubChem CID Link
• SMILES
  C1=CN=CC=C1C2=C(SC(=C2C3=CC=NC=C3)C4=CC=NC=C4)C5=CC=NC=C5
• InChi
  InChI=1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H
• InChi Key
  USWLOKMMUTWFMD-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GANT58  
• Short name
  GANT58
• Alternative name
  GANT58

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